Genetic epidemiology of chronic kidney disease

Michelle M. Estrella, Chistopher J. Sperati, Wen H.L. Kao, Rulan S. Parekh

Research output: Contribution to journalReview articlepeer-review


PURPOSE OF REVIEW: To provide a brief review of methods used in genetic epidemiology studies, an update of recent significant findings in genome-wide studies of kidney disease, and a discussion of the clinical implications of these findings. RECENT FINDINGS: Recent developments in genetic epidemiology methodologies, specifically the use of genome-wide panels of single nucleotide polymporphisms (SNPs) for association analyses, have yielded exciting insights into the underlying pathogenesis of chronic kidney disease and its progression. The two most notable and promising genetic discoveries are those of MYH9 and UMOD, both of which have been replicated in separate populations. SUMMARY: Genomic studies have the potential to yield exciting new areas of biological research, potential targets for treatment, and ultimately markers of disease risk. This review addresses recent genetic studies and their implications in chronic kidney disease care.

Original languageEnglish (US)
Pages (from-to)283-291
Number of pages9
JournalCurrent opinion in nephrology and hypertension
Issue number3
StatePublished - May 2010


  • Chronic kidney disease
  • Genetic
  • Genome-wide association study
  • MYH9
  • UMOD

ASJC Scopus subject areas

  • Internal Medicine
  • Nephrology


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