TY - JOUR
T1 - Genetic epidemiology of chronic kidney disease
AU - Estrella, Michelle M.
AU - Sperati, Chistopher J.
AU - Kao, Wen H.L.
AU - Parekh, Rulan S.
PY - 2010/5
Y1 - 2010/5
N2 - PURPOSE OF REVIEW: To provide a brief review of methods used in genetic epidemiology studies, an update of recent significant findings in genome-wide studies of kidney disease, and a discussion of the clinical implications of these findings. RECENT FINDINGS: Recent developments in genetic epidemiology methodologies, specifically the use of genome-wide panels of single nucleotide polymporphisms (SNPs) for association analyses, have yielded exciting insights into the underlying pathogenesis of chronic kidney disease and its progression. The two most notable and promising genetic discoveries are those of MYH9 and UMOD, both of which have been replicated in separate populations. SUMMARY: Genomic studies have the potential to yield exciting new areas of biological research, potential targets for treatment, and ultimately markers of disease risk. This review addresses recent genetic studies and their implications in chronic kidney disease care.
AB - PURPOSE OF REVIEW: To provide a brief review of methods used in genetic epidemiology studies, an update of recent significant findings in genome-wide studies of kidney disease, and a discussion of the clinical implications of these findings. RECENT FINDINGS: Recent developments in genetic epidemiology methodologies, specifically the use of genome-wide panels of single nucleotide polymporphisms (SNPs) for association analyses, have yielded exciting insights into the underlying pathogenesis of chronic kidney disease and its progression. The two most notable and promising genetic discoveries are those of MYH9 and UMOD, both of which have been replicated in separate populations. SUMMARY: Genomic studies have the potential to yield exciting new areas of biological research, potential targets for treatment, and ultimately markers of disease risk. This review addresses recent genetic studies and their implications in chronic kidney disease care.
KW - Chronic kidney disease
KW - Genetic
KW - Genome-wide association study
KW - MYH9
KW - UMOD
UR - http://www.scopus.com/inward/record.url?scp=77951451300&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77951451300&partnerID=8YFLogxK
U2 - 10.1097/MNH.0b013e328338185f
DO - 10.1097/MNH.0b013e328338185f
M3 - Review article
C2 - 20393286
AN - SCOPUS:77951451300
SN - 1062-4821
VL - 19
SP - 283
EP - 291
JO - Current opinion in nephrology and hypertension
JF - Current opinion in nephrology and hypertension
IS - 3
ER -