Genetic-environmental interactions in chronic airways obstruction

Muin J. Khoury, Terri L Beaty, Carol A. Newill, Steve Bryant, Bernice H. Cohen

Research output: Contribution to journalArticle

Abstract

To examine patterns of interaction between cigarette smoking and genetic factors in relation to airways obstruction, cross sectional data were analysed on 1787 white non-patient adult participants in a genetic-epidemiological study of airways obstruction (AO), defined as one-second forced expiratory volume FEV1 less than 68% of forced vital capacity FVC. Interaction was examined between smoking and each of four factors previously found to be related to AO: alpha-1 antitrypsin (PiZ allele), ABO blood groups (A antigen), ABH non-secretor status, and first degree relationship to a COPD or lung cancer patient. Multiple linear regression was used to test for interaction and adjust mean FEV1 (as a per cent of FVC) and prevalence of AO for age, sex, socioeconomic status, coffee and alcohol intake. Statistical interaction was observed between smoking (measured in pack-years) and two genetic factors (presence of blood A antigen and the family history). At higher pack-year levels, those individuals with the A antigen or the family history, but especially those with both factors had a much lower mean FEV1/FVC % and a much higher prevalence of AO than expected based on a simple additive model. On the other hand, there was no interaction between smoking and PiZ allele, or smoking and ABH secretor status. The findings suggest a possible biological interaction between cigarette smoke and the airways of individuals with blood group A antigen and familial lung disease. The findings also emphasize the role of genetic-environmental interactions in chronic diseases of multifactorial aetiology.

Original languageEnglish (US)
Pages (from-to)65-72
Number of pages8
JournalInternational Journal of Epidemiology
Volume15
Issue number1
DOIs
StatePublished - Mar 1986

Fingerprint

Airway Obstruction
Obstruction
Smoking
Antigens
Interaction
Blood Group Antigens
Blood
Alleles
alpha 1-Antitrypsin
Coffee
Vital Capacity
Forced Expiratory Volume
Pulmonary diseases
Social Class
Smoke
Tobacco Products
Chronic Obstructive Pulmonary Disease
Lung Diseases
Chronic Disease
Epidemiologic Studies

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Epidemiology

Cite this

Genetic-environmental interactions in chronic airways obstruction. / Khoury, Muin J.; Beaty, Terri L; Newill, Carol A.; Bryant, Steve; Cohen, Bernice H.

In: International Journal of Epidemiology, Vol. 15, No. 1, 03.1986, p. 65-72.

Research output: Contribution to journalArticle

Khoury, Muin J. ; Beaty, Terri L ; Newill, Carol A. ; Bryant, Steve ; Cohen, Bernice H. / Genetic-environmental interactions in chronic airways obstruction. In: International Journal of Epidemiology. 1986 ; Vol. 15, No. 1. pp. 65-72.
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