Genetic Engineering of Mesenchymal Stem Cells to Induce Their Migration and Survival

Adam Nowakowski, Piotr Walczak, Barbara Lukomska, Miroslaw Janowski

Research output: Contribution to journalReview articlepeer-review

Abstract

Mesenchymal stem cells (MSCs) are very attractive for regenerative medicine due to their relatively easy derivation and broad range of differentiation capabilities, either naturally or induced through cell engineering. However, efficient methods of delivery to diseased tissues and the long-term survival of grafted cells still need improvement. Here, we review genetic engineering approaches designed to enhance the migratory capacities of MSCs, as well as extend their survival after transplantation by the modulation of prosurvival approaches, including prevention of senescence and apoptosis. We highlight some of the latest examples that explore these pivotal points, which have great relevance in cell-based therapies.

Original languageEnglish (US)
Article number4956063
JournalStem Cells International
Volume2016
DOIs
StatePublished - 2016

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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