Genetic diversity of noroviruses circulating in a pediatric cohort in Bangladesh

Martha I. Nelson, Mustafa Mahfuz, Preeti Chhabra, Rashidul Haque, Jessica C. Seidman, Iqbal Hossain, Monica McGrath, A. M. Shamsir Ahmed, Stacey Knobler, Jan Vinjé, Tahmeed Ahmed

Research output: Contribution to journalArticle

Abstract

Noroviruses are a leading cause of diarrhea in children aged <5 years worldwide. We genotyped 88 viruses collected by active surveillance in a birth cohort of children <2 years of age in Dhaka, Bangladesh, during 2010-2013. Twenty-five of 31 (81%) established GI and GII genotypes were detected, with GII.4 as the predominant genotype (20%). Our results show that children in Bangladesh are infected with a great diversity of norovirus strains. Reinfections are common, but not with closely related genotypes. Birth cohort studies are critical to understand cross-protective immunity and advance the development of pediatric norovirus vaccines.

Original languageEnglish (US)
Pages (from-to)1937-1942
Number of pages6
JournalJournal of Infectious Diseases
Volume218
Issue number12
DOIs
StatePublished - Jan 1 2018

Keywords

  • Birth cohort study
  • Evolution
  • Genotyping
  • LMIC
  • Norovirus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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  • Cite this

    Nelson, M. I., Mahfuz, M., Chhabra, P., Haque, R., Seidman, J. C., Hossain, I., McGrath, M., Shamsir Ahmed, A. M., Knobler, S., Vinjé, J., & Ahmed, T. (2018). Genetic diversity of noroviruses circulating in a pediatric cohort in Bangladesh. Journal of Infectious Diseases, 218(12), 1937-1942. https://doi.org/10.1093/infdis/jiy454