Abstract
Noroviruses are a leading cause of diarrhea in children aged <5 years worldwide. We genotyped 88 viruses collected by active surveillance in a birth cohort of children <2 years of age in Dhaka, Bangladesh, during 2010-2013. Twenty-five of 31 (81%) established GI and GII genotypes were detected, with GII.4 as the predominant genotype (20%). Our results show that children in Bangladesh are infected with a great diversity of norovirus strains. Reinfections are common, but not with closely related genotypes. Birth cohort studies are critical to understand cross-protective immunity and advance the development of pediatric norovirus vaccines.
Original language | English (US) |
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Pages (from-to) | 1937-1942 |
Number of pages | 6 |
Journal | Journal of Infectious Diseases |
Volume | 218 |
Issue number | 12 |
DOIs | |
State | Published - Nov 5 2018 |
Keywords
- Birth cohort study
- Evolution
- Genotyping
- LMIC
- Norovirus
ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases