Abstract
Given recent advances in the field of molecular genetics, many have recognized the need to exploit either study designs or analytical methods to test hypotheses with gene-by-environment (G×E) interactions. The partial-collection designs, including case-only, partial case-control, and case-parent trio designs, have been suggested as attractive alternatives to the complete case-control design both for increased statistical efficiency and reduced data needs. However, common problems in genetic epidemiology studies, such as, presence of G×E correlation in the population, population mixture, and genotyping error may reduce the validity of these designs. On the basis of previous simulation studies and empirical data and given the potential limitations and uncertainty of assumptions of partial-collection designs, the case-control design is the optimal choice versus partial-collection designs.
Original language | English (US) |
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Pages (from-to) | 241-245 |
Number of pages | 5 |
Journal | Current Opinion in Genetics and Development |
Volume | 14 |
Issue number | 3 |
DOIs |
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State | Published - Jun 2004 |
Keywords
- FPR
- G×E
- OR
- false positive rate
- gene-by-environment
- odds ratio
ASJC Scopus subject areas
- Genetics
- Developmental Biology