Genetic determinants of target and novelty-related event-related potentials in the auditory oddball response

Jingyu Liu; Kent A. Kiehl; Godfrey Pearlson; Nora I. Perrone-Bizzozero; Tom Eichele; Vince D. Calhoun

doi:10.1016/j.neuroimage.2009.02.045

Genetic determinants of target and novelty-related event-related potentials in the auditory oddball response

Jingyu Liu, Kent A. Kiehl, Godfrey Pearlson, Nora I. Perrone-Bizzozero, Tom Eichele, Vince D. Calhoun

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Processing of novel and target stimuli in the auditory target detection or 'oddball' task encompasses the chronometry of perception, attention and working memory and is reflected in scalp recorded event-related potentials (ERPs). A variety of ERP components related to target and novelty processing have been described and extensively studied, and linked to deficits of cognitive processing. However, little is known about associations of genotypes with ERP endophenotypes. Here we sought to elucidate the genetic underpinnings of auditory oddball ERP components using a novel data analysis technique. A parallel independent component analysis of the electrophysiology and single nucleotide polymorphism (SNP) data was used to extract relations between patterns of ERP components and SNP associations purely based on an analysis incorporating higher order statistics. The method allows for broader associations of genotypes with phenotypes than traditional hypothesis-driven univariate correlational analyses. We show that target detection and processing of novel stimuli are both associated with a shared cluster of genes linked to the adrenergic and dopaminergic pathways. These results provide evidence of genetic influences on normal patterns of ERP generation during auditory target detection and novelty processing at the SNP association level.

Original language	English (US)
Pages (from-to)	809-816
Number of pages	8
Journal	NeuroImage
Volume	46
Issue number	3
DOIs	https://doi.org/10.1016/j.neuroimage.2009.02.045
State	Published - Jul 1 2009
Externally published	Yes

Keywords

Auditory oddball
Dopamine
Event-related potential
Norepinephrine
P3 component
Parallel independent component analysis
Single nucleotide polymorphism

ASJC Scopus subject areas

Neurology
Cognitive Neuroscience

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10.1016/j.neuroimage.2009.02.045

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@article{a9942ad30a7b407a92046d2ac6b9bad6,

title = "Genetic determinants of target and novelty-related event-related potentials in the auditory oddball response",

abstract = "Processing of novel and target stimuli in the auditory target detection or 'oddball' task encompasses the chronometry of perception, attention and working memory and is reflected in scalp recorded event-related potentials (ERPs). A variety of ERP components related to target and novelty processing have been described and extensively studied, and linked to deficits of cognitive processing. However, little is known about associations of genotypes with ERP endophenotypes. Here we sought to elucidate the genetic underpinnings of auditory oddball ERP components using a novel data analysis technique. A parallel independent component analysis of the electrophysiology and single nucleotide polymorphism (SNP) data was used to extract relations between patterns of ERP components and SNP associations purely based on an analysis incorporating higher order statistics. The method allows for broader associations of genotypes with phenotypes than traditional hypothesis-driven univariate correlational analyses. We show that target detection and processing of novel stimuli are both associated with a shared cluster of genes linked to the adrenergic and dopaminergic pathways. These results provide evidence of genetic influences on normal patterns of ERP generation during auditory target detection and novelty processing at the SNP association level.",

keywords = "Auditory oddball, Dopamine, Event-related potential, Norepinephrine, P3 component, Parallel independent component analysis, Single nucleotide polymorphism",

author = "Jingyu Liu and Kiehl, {Kent A.} and Godfrey Pearlson and Perrone-Bizzozero, {Nora I.} and Tom Eichele and Calhoun, {Vince D.}",

note = "Funding Information: This research was supported by the National Institutes of Health, under grants R01 EB 000840, R01 EB 005846 (to Dr. Calhoun), and RO1 MH43775, RO1 MH074797 and R01 MH077945 (to Dr. Pearlson), and R01 MH 071896-01, R01 MH 070539-01 and R01 MH 072681-01 (to Dr. Kiehl), and K23 MH 070036-01 (to Dr. Stevens). Dr. Eichele was supported by the L. Meltzer foundation (801616). Particular thanks go to Dr. Michael Stevens who has generously provided us the data for the study. We would also like to thank Genomas Inc. who conducted genotyping for all subjects, and in particular, give thanks to Dr. Gualberto Rua{\~n}o and Dr. Andreas Windemuth. ",

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doi = "10.1016/j.neuroimage.2009.02.045",

language = "English (US)",

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AU - Liu, Jingyu

AU - Kiehl, Kent A.

AU - Pearlson, Godfrey

AU - Perrone-Bizzozero, Nora I.

AU - Eichele, Tom

AU - Calhoun, Vince D.

N1 - Funding Information: This research was supported by the National Institutes of Health, under grants R01 EB 000840, R01 EB 005846 (to Dr. Calhoun), and RO1 MH43775, RO1 MH074797 and R01 MH077945 (to Dr. Pearlson), and R01 MH 071896-01, R01 MH 070539-01 and R01 MH 072681-01 (to Dr. Kiehl), and K23 MH 070036-01 (to Dr. Stevens). Dr. Eichele was supported by the L. Meltzer foundation (801616). Particular thanks go to Dr. Michael Stevens who has generously provided us the data for the study. We would also like to thank Genomas Inc. who conducted genotyping for all subjects, and in particular, give thanks to Dr. Gualberto Ruaño and Dr. Andreas Windemuth.

PY - 2009/7/1

Y1 - 2009/7/1

N2 - Processing of novel and target stimuli in the auditory target detection or 'oddball' task encompasses the chronometry of perception, attention and working memory and is reflected in scalp recorded event-related potentials (ERPs). A variety of ERP components related to target and novelty processing have been described and extensively studied, and linked to deficits of cognitive processing. However, little is known about associations of genotypes with ERP endophenotypes. Here we sought to elucidate the genetic underpinnings of auditory oddball ERP components using a novel data analysis technique. A parallel independent component analysis of the electrophysiology and single nucleotide polymorphism (SNP) data was used to extract relations between patterns of ERP components and SNP associations purely based on an analysis incorporating higher order statistics. The method allows for broader associations of genotypes with phenotypes than traditional hypothesis-driven univariate correlational analyses. We show that target detection and processing of novel stimuli are both associated with a shared cluster of genes linked to the adrenergic and dopaminergic pathways. These results provide evidence of genetic influences on normal patterns of ERP generation during auditory target detection and novelty processing at the SNP association level.

AB - Processing of novel and target stimuli in the auditory target detection or 'oddball' task encompasses the chronometry of perception, attention and working memory and is reflected in scalp recorded event-related potentials (ERPs). A variety of ERP components related to target and novelty processing have been described and extensively studied, and linked to deficits of cognitive processing. However, little is known about associations of genotypes with ERP endophenotypes. Here we sought to elucidate the genetic underpinnings of auditory oddball ERP components using a novel data analysis technique. A parallel independent component analysis of the electrophysiology and single nucleotide polymorphism (SNP) data was used to extract relations between patterns of ERP components and SNP associations purely based on an analysis incorporating higher order statistics. The method allows for broader associations of genotypes with phenotypes than traditional hypothesis-driven univariate correlational analyses. We show that target detection and processing of novel stimuli are both associated with a shared cluster of genes linked to the adrenergic and dopaminergic pathways. These results provide evidence of genetic influences on normal patterns of ERP generation during auditory target detection and novelty processing at the SNP association level.

KW - Auditory oddball

KW - Dopamine

KW - Event-related potential

KW - Norepinephrine

KW - P3 component

KW - Parallel independent component analysis

KW - Single nucleotide polymorphism

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JO - NeuroImage

JF - NeuroImage

IS - 3

ER -

Genetic determinants of target and novelty-related event-related potentials in the auditory oddball response

Abstract

Keywords

ASJC Scopus subject areas

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