TY - JOUR
T1 - Genetic determinants of responsiveness to antiplatelet therapy
AU - Kral, Brian G.
AU - Lawal, Lookman
AU - Becker, Lewis
PY - 2008
Y1 - 2008
N2 - Antiplatelet drugs are well-established therapies for acute coronary syndromes and for the primary and secondary prevention of coronary artery disease, stroke, and peripheral vascular disease. However, wide interindividual variability exists in the degree of platelet suppression among patients treated with antiplatelet drugs, and many individuals develop atherothrombotic events while on therapy. Although many potential mechanisms may contribute to the response variation observed, there is accumulating evidence that polymorphisms of genes from multiple biologic pathways involved in platelet activation are at least partly responsible for variable platelet responsiveness and potentially responsible for clinical failure of antiplatelet therapy.
AB - Antiplatelet drugs are well-established therapies for acute coronary syndromes and for the primary and secondary prevention of coronary artery disease, stroke, and peripheral vascular disease. However, wide interindividual variability exists in the degree of platelet suppression among patients treated with antiplatelet drugs, and many individuals develop atherothrombotic events while on therapy. Although many potential mechanisms may contribute to the response variation observed, there is accumulating evidence that polymorphisms of genes from multiple biologic pathways involved in platelet activation are at least partly responsible for variable platelet responsiveness and potentially responsible for clinical failure of antiplatelet therapy.
UR - http://www.scopus.com/inward/record.url?scp=84873493390&partnerID=8YFLogxK
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U2 - 10.1007/s12170-008-0084-2
DO - 10.1007/s12170-008-0084-2
M3 - Article
AN - SCOPUS:84873493390
SN - 1932-9520
VL - 2
SP - 476
EP - 484
JO - Current Cardiovascular Risk Reports
JF - Current Cardiovascular Risk Reports
IS - 6
ER -