Genetic counseling and genetic testing in the preoperative evaluation of breast cancer patients

David M Euhus, Linda Robinson

Research output: Contribution to journalArticle

Abstract

Breast cancers arising in the context of germline BRCA gene mutation have unique biological features that must be considered during treatment planning. Breast conserving surgery is an acceptable option in highly motivated women who are fully informed about the risks of ipsilateral breast tumor recurrence and contralateral breast cancer. Partial breast irradiation is not recommended for these women. Concurrent bilateral salpingo-oophorectomy should be considered. BRCA1- associated breast cancer may be resistant to taxanes, but appears highly sensitive to platinum agents and to PARP inhibitors. Preoperative genetic testing can be accomplished with short turn around times and does not increase patient anxiety. Inclusion of a professional genetic counselor in the management team is essential. BRCA gene mutation status is emerging as an important prognostic and predictive factor for breast cancer patients. Preoperative genetic counseling and testing is recommended for women likely to carry a BRCA gene mutation.

Original languageEnglish (US)
Pages (from-to)102-109
Number of pages8
JournalCurrent Breast Cancer Reports
Volume4
Issue number2
DOIs
StatePublished - Jun 2012
Externally publishedYes

Fingerprint

Genetic Counseling
Genetic Testing
Breast Neoplasms
Mutation
Genes
Taxoids
Segmental Mastectomy
Ovariectomy
Platinum
Breast
Anxiety
Recurrence

Keywords

  • Anxiety
  • Bilateral salpingo-oophorectomy
  • BRCA1
  • BRCA2
  • Breast cancer
  • Breast conserving surgery
  • Chemotherapy
  • Cisplatin
  • Contralateral breast cancer
  • Genetic counseling
  • Genetic testing
  • Hysterectomy. Preoperative
  • Ipsilateral breast tumor recurrence
  • Mastectomy
  • PARPinhibition
  • Radiation
  • Recurrence
  • Survival
  • Tamoxifen

ASJC Scopus subject areas

  • Oncology

Cite this

Genetic counseling and genetic testing in the preoperative evaluation of breast cancer patients. / Euhus, David M; Robinson, Linda.

In: Current Breast Cancer Reports, Vol. 4, No. 2, 06.2012, p. 102-109.

Research output: Contribution to journalArticle

@article{1f01a183fe0f43a2998b59101ceb2e16,
title = "Genetic counseling and genetic testing in the preoperative evaluation of breast cancer patients",
abstract = "Breast cancers arising in the context of germline BRCA gene mutation have unique biological features that must be considered during treatment planning. Breast conserving surgery is an acceptable option in highly motivated women who are fully informed about the risks of ipsilateral breast tumor recurrence and contralateral breast cancer. Partial breast irradiation is not recommended for these women. Concurrent bilateral salpingo-oophorectomy should be considered. BRCA1- associated breast cancer may be resistant to taxanes, but appears highly sensitive to platinum agents and to PARP inhibitors. Preoperative genetic testing can be accomplished with short turn around times and does not increase patient anxiety. Inclusion of a professional genetic counselor in the management team is essential. BRCA gene mutation status is emerging as an important prognostic and predictive factor for breast cancer patients. Preoperative genetic counseling and testing is recommended for women likely to carry a BRCA gene mutation.",
keywords = "Anxiety, Bilateral salpingo-oophorectomy, BRCA1, BRCA2, Breast cancer, Breast conserving surgery, Chemotherapy, Cisplatin, Contralateral breast cancer, Genetic counseling, Genetic testing, Hysterectomy. Preoperative, Ipsilateral breast tumor recurrence, Mastectomy, PARPinhibition, Radiation, Recurrence, Survival, Tamoxifen",
author = "Euhus, {David M} and Linda Robinson",
year = "2012",
month = "6",
doi = "10.1007/s12609-012-0071-y",
language = "English (US)",
volume = "4",
pages = "102--109",
journal = "Current Breast Cancer Reports",
issn = "1943-4588",
publisher = "Current Science, Inc.",
number = "2",

}

TY - JOUR

T1 - Genetic counseling and genetic testing in the preoperative evaluation of breast cancer patients

AU - Euhus, David M

AU - Robinson, Linda

PY - 2012/6

Y1 - 2012/6

N2 - Breast cancers arising in the context of germline BRCA gene mutation have unique biological features that must be considered during treatment planning. Breast conserving surgery is an acceptable option in highly motivated women who are fully informed about the risks of ipsilateral breast tumor recurrence and contralateral breast cancer. Partial breast irradiation is not recommended for these women. Concurrent bilateral salpingo-oophorectomy should be considered. BRCA1- associated breast cancer may be resistant to taxanes, but appears highly sensitive to platinum agents and to PARP inhibitors. Preoperative genetic testing can be accomplished with short turn around times and does not increase patient anxiety. Inclusion of a professional genetic counselor in the management team is essential. BRCA gene mutation status is emerging as an important prognostic and predictive factor for breast cancer patients. Preoperative genetic counseling and testing is recommended for women likely to carry a BRCA gene mutation.

AB - Breast cancers arising in the context of germline BRCA gene mutation have unique biological features that must be considered during treatment planning. Breast conserving surgery is an acceptable option in highly motivated women who are fully informed about the risks of ipsilateral breast tumor recurrence and contralateral breast cancer. Partial breast irradiation is not recommended for these women. Concurrent bilateral salpingo-oophorectomy should be considered. BRCA1- associated breast cancer may be resistant to taxanes, but appears highly sensitive to platinum agents and to PARP inhibitors. Preoperative genetic testing can be accomplished with short turn around times and does not increase patient anxiety. Inclusion of a professional genetic counselor in the management team is essential. BRCA gene mutation status is emerging as an important prognostic and predictive factor for breast cancer patients. Preoperative genetic counseling and testing is recommended for women likely to carry a BRCA gene mutation.

KW - Anxiety

KW - Bilateral salpingo-oophorectomy

KW - BRCA1

KW - BRCA2

KW - Breast cancer

KW - Breast conserving surgery

KW - Chemotherapy

KW - Cisplatin

KW - Contralateral breast cancer

KW - Genetic counseling

KW - Genetic testing

KW - Hysterectomy. Preoperative

KW - Ipsilateral breast tumor recurrence

KW - Mastectomy

KW - PARPinhibition

KW - Radiation

KW - Recurrence

KW - Survival

KW - Tamoxifen

UR - http://www.scopus.com/inward/record.url?scp=84863723940&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863723940&partnerID=8YFLogxK

U2 - 10.1007/s12609-012-0071-y

DO - 10.1007/s12609-012-0071-y

M3 - Article

AN - SCOPUS:84863723940

VL - 4

SP - 102

EP - 109

JO - Current Breast Cancer Reports

JF - Current Breast Cancer Reports

SN - 1943-4588

IS - 2

ER -