Genetic control of basal serum immunoglobulin E level and its effect on specific reaginic sensitivity

D. G. Marsh, W. B. Bias, K. Ishizaka

Research output: Contribution to journalArticle

Abstract

Studies of the distribution of total serum immunoglobulin E levels in nonallergic and allergic populations defined a cut off point between low and high immunoglobulin E at 95 U/ml, based on Mendelian recessive inheritance of high immunoglobulin E level. Subsequent investigations of the distribution of total serum immunoglobulin E levels in 28 allergic families confirmed the recessive hypothesis. The results of quantitative skin tests in eight families, performed with between five and eight highly purified grass and ragweed pollen allergens per family, demonstrate that the immunoglobulin E regulating gene exerts a profound effect on specific immunoglobulin E mediated sensitivity, often masking the effect of HL A associated immune response genes.

Original languageEnglish (US)
Pages (from-to)3588-3592
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume71
Issue number9
Publication statusPublished - 1974

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ASJC Scopus subject areas

  • General
  • Genetics

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