Genetic contribution to factor VII levels in families of patients undergoing coronary arteriography

S. H. Jee, K. S. Song, W. Shim, H. K. Kim, I. Suh, Y. Yoon, Terri L Beaty

Research output: Contribution to journalArticle

Abstract

An elevated plasma level of factor VII is a risk factor for coronary artery disease. We investigated environmental, familial, and genetic influences on factor VII activity in 508 family members of 87 probands who underwent elective coronary arteriography. Maximum likelihood methods were used to fit several genetic and non-genetic models of inheritance to these data to determine whether an unobserved Mendelian major gene could explain the familial distribution of factor VII. Factor VII activities were adjusted for age, gender, body mass index, smoking, alcohol consumption, menopause status, and triglycerides prior to this segregation analysis (this model accounted for 33.5% of the total variation). Adjusted factor VII activities showed strong familial aggregation with an estimated parent-offspring correlation of 0.34, sibling correlation of 0.36 and a smaller spouse correlation of 0.16. Regressive models were used to test genetic and non-genetic models in these 87 families. Mendelian single-locus models with either two or three underlying genotypic distributions of factor VII activities were best supported by these data. Essentially, these Mendelian models suggest most individuals come from a low distribution (mean, 116%), with a few individuals homozygous for a high allele drawn from a distribution with a mean of 166%. Future linkage studies may be worthwhile to further clarify the mechanisms controlling factor VII activity.

Original languageEnglish (US)
Pages (from-to)25-33
Number of pages9
JournalBlood Coagulation and Fibrinolysis
Volume13
Issue number1
DOIs
StatePublished - 2002

Fingerprint

Factor VII
Angiography
Menopause
Spouses
Alcohol Drinking
Siblings
Coronary Artery Disease
Triglycerides
Body Mass Index
Smoking
Alleles
Genes

Keywords

  • Factor VII activity
  • Segregation analysis

ASJC Scopus subject areas

  • Hematology

Cite this

Genetic contribution to factor VII levels in families of patients undergoing coronary arteriography. / Jee, S. H.; Song, K. S.; Shim, W.; Kim, H. K.; Suh, I.; Yoon, Y.; Beaty, Terri L.

In: Blood Coagulation and Fibrinolysis, Vol. 13, No. 1, 2002, p. 25-33.

Research output: Contribution to journalArticle

Jee, S. H. ; Song, K. S. ; Shim, W. ; Kim, H. K. ; Suh, I. ; Yoon, Y. ; Beaty, Terri L. / Genetic contribution to factor VII levels in families of patients undergoing coronary arteriography. In: Blood Coagulation and Fibrinolysis. 2002 ; Vol. 13, No. 1. pp. 25-33.
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