Genetic characterization of HIV-1 from semen and blood from clade C-infected subjects from India and effect of therapy in these body compartments

Chengli Shen, Ming Ding, Jodi K. Craigo, Patrick Tarwater, Ramdas Chatterjee, Pratima Roy, Subhasish K. Guha, Bibhuti Saha, Dolonchapa Modak, Dhrubak Neogi, Yue Chen, Phalguni Gupta

Research output: Contribution to journalArticlepeer-review

Abstract

Biologic and genetic differences between HIV-1 clade C in India and clade B in US suggest that the effect of anti-viral therapy in various body compartments may differ between these two clades. We examined the effect of therapy on viral loads in semen and blood of HIV-1-clade C infected subjects from India and evaluated whether HIV-1 in the semen is different from that in blood in these subjects. HIV-1 RNA was detected in semen and blood at all stages of the disease. Viral loads in semen and blood were strongly correlated with each other, but not with the CD4+ T cell count. Anti-viral treatment reduced viral load drastically in blood and semen within one month of post therapy. Genetic characterization of HIV-1 in the semen and blood demonstrated that they were highly compartmentalized. These data have important implications of sexual transmission of HIV-1 in clade C HIV-1 infected subjects.

Original languageEnglish (US)
Pages (from-to)190-196
Number of pages7
JournalVirology
Volume401
Issue number2
DOIs
StatePublished - Jun 2010

Keywords

  • Antiretroviral therapy
  • Clade C HIV-1
  • Semen

ASJC Scopus subject areas

  • Virology

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