Genetic characterization of an H2N2 influenza virus isolated from a muskrat in Western Siberia

Marina Gulyaeva, Kirill Sharshov, Mizuho Suzuki, Ivan Sobolev, Yoshihiro Sakoda, Alexander Alekseev, Mariya Sivay, Lidia Shestopalova, Michael Shchelkanov, Alexander Shestopalov

Research output: Contribution to journalArticle

Abstract

Thirty-two muskrats (Ondatra zibethicus) were captured for surveillance of avian influenza virus in wild waterfowl and mammals near Lake Chany, Western Siberia, Russia. A/muskrat/Russia/63/2014 (H2N2) was isolated from an apparently healthy muskrat using chicken embryos. Based on phylogenetic analysis, the hemagglutinin and neuraminidase genes of this isolate were classified into the Eurasian avian-like influenza virus clade and closely related to low pathogenic avian influenza viruses (LPAIVs) isolated from wild water birds in Italy and Sweden, respectively. Other internal genes were also closely related to LPAIVs isolated from Eurasian wild water birds. Results suggest that interspecies transmission of LPAIVs from wild water birds to semiaquatic mammals occurs, facilitating the spread and evolution of LPAIVs in wetland areas of Western Siberia.

Original languageEnglish (US)
Pages (from-to)1461-1465
Number of pages5
JournalJournal of Veterinary Medical Science
Volume79
Issue number8
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

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Keywords

  • H2N2
  • Influenza virus
  • Muskrat
  • Phylogenetic analysis
  • Siberia

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Gulyaeva, M., Sharshov, K., Suzuki, M., Sobolev, I., Sakoda, Y., Alekseev, A., Sivay, M., Shestopalova, L., Shchelkanov, M., & Shestopalov, A. (2017). Genetic characterization of an H2N2 influenza virus isolated from a muskrat in Western Siberia. Journal of Veterinary Medical Science, 79(8), 1461-1465. https://doi.org/10.1292/jvms.17-0048