@article{0cbe765dad4c4ba89ae1852025e8d1c7,
title = "Genetic characterization of a captive colony of pigtailed Macaques (Macaca nemestrina)",
abstract = "Effective colony management is critical to guarantee the availability of captive NHP as subjects for biomedical research. Pigtailed macaques (Macaca nemestrina) are an important model for the study of human and nonhuman primate diseases and behavior. Johns Hopkins University hosts one of the largest captive colonies of pigtailed macaques in the United States. In this study, we used 56 single-nucleotide polymorphisms (SNP) to characterize this population of pigtailed macaques, understand their population structure, and assess the effectiveness of their colony management. The results demonstrate that the colony has maintained a high level of genetic diversity, with no loss of heterozygosity since its origin, and low levels of inbreeding and genetic subdivision.",
author = "Xinjun Zhang and Sree Kanthaswamy and Trask, {Jessica S.} and Jillian Ng and Oldt, {Robert F.} and Mankowski, {Joseph L.} and Adams, {Robert J.} and Smith, {David G.}",
note = "Funding Information: This study was supported by the California National Primate Research Center base grant (No. RR000169-48), by grants RR005090 and RR025781 to DGS from the National Center for Research Resources of NIH, and by P40 OD0131117 (NIH) to RJA. This research adhered to the American Society of Primatologists principles for the ethical treatment of NHP, and the animals used have been managed in compliance with IACUC regulations or in accordance with the NIH guidelines or the US Department of Agriculture regulations prescribing the humane care and use of laboratory animals. We thank the Molecular Anthropology Laboratory (MAL) of Department of Anthropology at UC Davis for providing facility support for this study and the Genome Center of UC Davis for performing genotyping assay. We also thank Johns Hopkins University for providing the samples used in this study. Publisher Copyright: Copyright 2017 by the American Association for Laboratory Animal Science.",
year = "2017",
month = jul,
language = "English (US)",
volume = "56",
pages = "390--395",
journal = "Journal of the American Association for Laboratory Animal Science",
issn = "1559-6109",
publisher = "American Association for Laboratory Animal Science",
number = "4",
}