Genetic characterization of a captive colony of pigtailed Macaques (Macaca nemestrina)

Xinjun Zhang, Sree Kanthaswamy, Jessica S. Trask, Jillian Ng, Robert F. Oldt, Joseph L. Mankowski, Robert J. Adams, David G. Smith

Research output: Research - peer-reviewArticle

Abstract

Effective colony management is critical to guarantee the availability of captive NHP as subjects for biomedical research. Pigtailed macaques (Macaca nemestrina) are an important model for the study of human and nonhuman primate diseases and behavior. Johns Hopkins University hosts one of the largest captive colonies of pigtailed macaques in the United States. In this study, we used 56 single-nucleotide polymorphisms (SNP) to characterize this population of pigtailed macaques, understand their population structure, and assess the effectiveness of their colony management. The results demonstrate that the colony has maintained a high level of genetic diversity, with no loss of heterozygosity since its origin, and low levels of inbreeding and genetic subdivision.

LanguageEnglish (US)
Pages390-395
Number of pages6
JournalJournal of the American Association for Laboratory Animal Science
Volume56
Issue number4
StatePublished - Jul 1 2017

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Macaca nemestrina
biomedical research
inbreeding
single nucleotide polymorphism
heterozygosity
population structure
Primates
genetic variation

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Genetic characterization of a captive colony of pigtailed Macaques (Macaca nemestrina). / Zhang, Xinjun; Kanthaswamy, Sree; Trask, Jessica S.; Ng, Jillian; Oldt, Robert F.; Mankowski, Joseph L.; Adams, Robert J.; Smith, David G.

In: Journal of the American Association for Laboratory Animal Science, Vol. 56, No. 4, 01.07.2017, p. 390-395.

Research output: Research - peer-reviewArticle

Zhang, Xinjun ; Kanthaswamy, Sree ; Trask, Jessica S. ; Ng, Jillian ; Oldt, Robert F. ; Mankowski, Joseph L. ; Adams, Robert J. ; Smith, David G./ Genetic characterization of a captive colony of pigtailed Macaques (Macaca nemestrina). In: Journal of the American Association for Laboratory Animal Science. 2017 ; Vol. 56, No. 4. pp. 390-395
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