Genetic changes and DNA damage responses in the prostate

Taija M. Kiviharju-af Hällström, Marikki Laiho

Research output: Contribution to journalArticle

Abstract

The integrity of genomic DNA is challenged by genotoxic stress originating during normal cellular metabolism or by external insults. Cellular responses to DNA damage involve elegant checkpoint cascades enforcing cell cycle arrest, damage repair, apoptosis or cellular senescence. The loss or alterations of genes involved in the damage response pathways have been reported in many cancer susceptibility syndromes and in sporadic tumors. Furthermore, this surveillance pathway is activated during early tumourigenesis presumably due to uncontrolled replicative cycles and has been recognized as one of the main barriers against the development of cancer. This review discusses the relevance of prostatic epithelial cells in prostate tumourigenesis and highlights common molecular changes associated with prostate cancer. Furthermore, DNA damage responses of primary cultures of human prostatic epithelial cells and fresh human prostate tissues are discussed providing evidence for alterations in crucial DNA damage checkpoint molecules. New insights connecting prostate tumourigenesis to alterations and defects in the pathways maintaining genomic integrity will be discussed.

Original languageEnglish (US)
Pages (from-to)902-918
Number of pages17
JournalProstate
Volume68
Issue number8
DOIs
StatePublished - Jun 1 2008

Fingerprint

DNA Damage
Prostate
Epithelial Cells
Neoplasms
Cell Aging
Cell Cycle Checkpoints
Prostatic Neoplasms
Apoptosis
DNA
Genes

Keywords

  • DNA damage checkpoint
  • Genetic alteration
  • p53
  • Radiation

ASJC Scopus subject areas

  • Urology

Cite this

Genetic changes and DNA damage responses in the prostate. / Kiviharju-af Hällström, Taija M.; Laiho, Marikki.

In: Prostate, Vol. 68, No. 8, 01.06.2008, p. 902-918.

Research output: Contribution to journalArticle

Kiviharju-af Hällström, Taija M. ; Laiho, Marikki. / Genetic changes and DNA damage responses in the prostate. In: Prostate. 2008 ; Vol. 68, No. 8. pp. 902-918.
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