Genetic basis of pancreas cancer development and progression: Insights from whole-exome and whole-genome sequencing

Research output: Contribution to journalArticle

Abstract

Pancreatic cancer is caused by inherited and acquired mutations in specific cancer-associated genes. The discovery of the most common genetic alterations in pancreatic cancer has provided insight into the fundamental pathways that drive the progression from a normal cell to noninvasive precursor lesions and finally to widely metastatic disease. In addition, recent genetic discoveries have created new opportunities to develop gene-based approaches for early detection, personalized treatment, and molecular classification of pancreatic neoplasms.

Original languageEnglish (US)
Pages (from-to)4257-4265
Number of pages9
JournalClinical Cancer Research
Volume18
Issue number16
DOIs
StatePublished - Aug 15 2012

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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