Genetic basis of ige responsiveness: Relevance to the atopic diseases

David G. Marsh; John D. Neely; Daniel R. Breazeale; Balaram Ghosh; Linda R. Freidhoff; Carsten Schou; Terri H. Beaty

doi:10.1159/000236920

Genetic basis of ige responsiveness: Relevance to the atopic diseases

David G. Marsh, John D. Neely, Daniel R. Breazeale, Balaram Ghosh, Linda R. Freidhoff, Carsten Schou, Terri H. Beaty

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Genctic analysis of 170 subjects in 11 extended Amish families revealed evidence for linkage of five markers in chromosome 5q31.l with a gene controlling total serum IgE levels. No linkage was found between these markers and specific IgE antibody levels. Analysis of total IgE within a subset of 128 IgE-antibodynegative sib pairs confirmed evidence for linkage to 5q31.1, especially IL4 (p = 4 x l0^-6). These and other data suggest that 1L4 or a nearby gene regulates IgE production in a non-antigen-specific (noncognate) fashion and provide evidence for a possible link between asthma and the.

Original language	English (US)
Pages (from-to)	25-28
Number of pages	4
Journal	International archives of allergy and immunology
Volume	107
Issue number	1-3
DOIs	https://doi.org/10.1159/000236920
State	Published - 1995

Keywords

Asthma
Gcnctic analysis
Igegene
Il4
Noncognate ige production

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1159/000236920

Cite this

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title = "Genetic basis of ige responsiveness: Relevance to the atopic diseases",

abstract = "Genctic analysis of 170 subjects in 11 extended Amish families revealed evidence for linkage of five markers in chromosome 5q31.l with a gene controlling total serum IgE levels. No linkage was found between these markers and specific IgE antibody levels. Analysis of total IgE within a subset of 128 IgE-antibodynegative sib pairs confirmed evidence for linkage to 5q31.1, especially IL4 (p = 4 x l0-6). These and other data suggest that 1L4 or a nearby gene regulates IgE production in a non-antigen-specific (noncognate) fashion and provide evidence for a possible link between asthma and the.",

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T1 - Genetic basis of ige responsiveness

T2 - Relevance to the atopic diseases

AU - Marsh, David G.

AU - Neely, John D.

AU - Breazeale, Daniel R.

AU - Ghosh, Balaram

AU - Freidhoff, Linda R.

AU - Schou, Carsten

AU - Beaty, Terri H.

PY - 1995

Y1 - 1995

N2 - Genctic analysis of 170 subjects in 11 extended Amish families revealed evidence for linkage of five markers in chromosome 5q31.l with a gene controlling total serum IgE levels. No linkage was found between these markers and specific IgE antibody levels. Analysis of total IgE within a subset of 128 IgE-antibodynegative sib pairs confirmed evidence for linkage to 5q31.1, especially IL4 (p = 4 x l0-6). These and other data suggest that 1L4 or a nearby gene regulates IgE production in a non-antigen-specific (noncognate) fashion and provide evidence for a possible link between asthma and the.

AB - Genctic analysis of 170 subjects in 11 extended Amish families revealed evidence for linkage of five markers in chromosome 5q31.l with a gene controlling total serum IgE levels. No linkage was found between these markers and specific IgE antibody levels. Analysis of total IgE within a subset of 128 IgE-antibodynegative sib pairs confirmed evidence for linkage to 5q31.1, especially IL4 (p = 4 x l0-6). These and other data suggest that 1L4 or a nearby gene regulates IgE production in a non-antigen-specific (noncognate) fashion and provide evidence for a possible link between asthma and the.

KW - Asthma

KW - Gcnctic analysis

KW - Igegene

KW - Il4

KW - Noncognate ige production

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Genetic basis of ige responsiveness: Relevance to the atopic diseases

Abstract

Keywords

ASJC Scopus subject areas

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