@article{5ba9947780ee4fc6813ac73c4d372046,
title = "Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection",
abstract = "Background: High-throughput genome-wide techniques have facilitated the identification of previously unknown host proteins involved in cellular human immunodeficiency virus (HIV) infection. Recently, 3 independent studies have used small interfering RNA technology to silence each gene in the human genome to determine the importance of each in HIV infection. Genes conferring a significant effect were termed HIV-dependency factors (HDFs). Methods: We assembled high-density panels of 6380 single-nucleotide polymorphisms (SNPs) in 278 HDF genes and tested for genotype associations with HIV infection and AIDS progression in 1633 individuals from clinical AIDS cohorts. Results: After statistical correction for multiple tests, significant associations with HIV acquisition were found for SNPs in 2 genes, NCOR2 and IDH1. Weaker associations with AIDS progression were revealed for SNPs within the TM9SF2 and EGFR genes. Conclusions: This study independently verifies the influence of NCOR2 and IDH1 on HIV transmission, and its findings suggest that variation in these genes affects susceptibility to HIV infection in exposed individuals.",
author = "Chinn, {Leslie W.} and Minzhong Tang and Kessing, {Bailey D.} and Lautenberger, {James A.} and Troyer, {Jennifer L.} and Malasky, {Michael J.} and Carl McIntosh and Kirk, {Gregory D.} and Wolinsky, {Steven M.} and Buchbinder, {Susan P.} and Gomperts, {Edward D.} and Goedert, {James J.} and O'Brien, {Stephen J.}",
note = "Funding Information: Financial support: This project has been funded in whole or in part with federal funds from the National Cancer Institute (NCI), National Institutes of Health (NIH; contract HHSN261200800001E). AIDS Link to the Intravenous Experience was supported by NIH grants R01-DA-04334 and R01-DA-12568. Multicenter AIDS Cohort Study work was supported by NIH grants UO1-AI-35042, 5-MO1-RR-00722 (GCRC), UO1-AI-35043, UO1-AI-37984, UO1-AI-35039, UO1-AI-35040, UO1-AI-37613, UO1-AI-35041, and M01 RR00425 (National Center for Research Resources grant awarded to the GCRC at Harbor–University of California, Los Angeles, Research and Education Institute). The Multicenter Hemophilia Cohort Study is supported by NCI contract N02-CP-55504 with RTI International. The Hemophilia Growth and Development Study is funded by the NIH, National Institute of Child Health and Human Development, grant 1 R01 HD41224. NCI contracts include the following: UO1-AI-35042, 5-MO1-RR-00722 (GCRC), UO1-AI-35043, UO1-AI-37984, UO1-AI-35039, UO1-AI-35040, UO1-AI-37613, and UO1-AI-35041. This project has been funded in whole or in part with federal funds from the NCI, NIH, under contract N01-CO-12400. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.",
year = "2010",
month = dec,
day = "15",
doi = "10.1086/657322",
language = "English (US)",
volume = "202",
pages = "1836--1845",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "12",
}