Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection

Leslie W. Chinn, Minzhong Tang, Bailey D. Kessing, James A. Lautenberger, Jennifer L. Troyer, Michael J. Malasky, Carl McIntosh, Gregory D Kirk, Steven M. Wolinsky, Susan P. Buchbinder, Edward D. Gomperts, James J. Goedert, Stephen J. O'Brien

Research output: Contribution to journalArticle

Abstract

Background: High-throughput genome-wide techniques have facilitated the identification of previously unknown host proteins involved in cellular human immunodeficiency virus (HIV) infection. Recently, 3 independent studies have used small interfering RNA technology to silence each gene in the human genome to determine the importance of each in HIV infection. Genes conferring a significant effect were termed HIV-dependency factors (HDFs). Methods: We assembled high-density panels of 6380 single-nucleotide polymorphisms (SNPs) in 278 HDF genes and tested for genotype associations with HIV infection and AIDS progression in 1633 individuals from clinical AIDS cohorts. Results: After statistical correction for multiple tests, significant associations with HIV acquisition were found for SNPs in 2 genes, NCOR2 and IDH1. Weaker associations with AIDS progression were revealed for SNPs within the TM9SF2 and EGFR genes. Conclusions: This study independently verifies the influence of NCOR2 and IDH1 on HIV transmission, and its findings suggest that variation in these genes affects susceptibility to HIV infection in exposed individuals.

Original languageEnglish (US)
Pages (from-to)1836-1845
Number of pages10
JournalJournal of Infectious Diseases
Volume202
Issue number12
DOIs
Publication statusPublished - Dec 15 2010

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ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

Cite this

Chinn, L. W., Tang, M., Kessing, B. D., Lautenberger, J. A., Troyer, J. L., Malasky, M. J., ... O'Brien, S. J. (2010). Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. Journal of Infectious Diseases, 202(12), 1836-1845. https://doi.org/10.1086/657322