Genetic association test based on principal component analysis

Zhongxue Chen, Shizhong Han, Kai Wang

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Many gene- A nd pathway-based association tests have been proposed in the literature. Among them, the SKAT is widely used, especially for rare variants association studies. In this paper, we investigate the connection between SKAT and a principal component analysis. This investigation leads to a procedure that encompasses SKAT as a special case. Through simulation studies and real data applications, we compare the proposed method with some existing tests.

Original languageEnglish (US)
Pages (from-to)189-198
Number of pages10
JournalStatistical Applications in Genetics and Molecular Biology
Issue number3
StatePublished - Jul 26 2017
Externally publishedYes


  • gene-based association
  • pathway-based association
  • rare variants

ASJC Scopus subject areas

  • Statistics and Probability
  • Molecular Biology
  • Genetics
  • Computational Mathematics


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