TY - JOUR
T1 - Genetic association between the phospholipase A2 gene and unipolar affective disorder
T2 - A multicentre case-control study
AU - Papadimitriou, George N.
AU - Dikeos, Dimitris G.
AU - Souery, Daniel
AU - Del-Favero, Jurgen
AU - Massat, Isabelle
AU - Avramopoulos, Dimitrios
AU - Blairy, Sylvie
AU - Cichon, Sven
AU - Ivezic, Sladjana
AU - Kaneva, Radka
AU - Karadima, Georgia
AU - Lilli, Roberta
AU - Milanova, Vihra
AU - Nöthen, Markus
AU - Oruc, Lilijana
AU - Rietschel, Marcella
AU - Serretti, Alessandro
AU - Van Broeckhoven, Christine
AU - Stefanis, Costas N.
AU - Mendlewicz, Julien
PY - 2003/12
Y1 - 2003/12
N2 - The co-segregation in one pedigree of bipolar affective disorder with Darier's disease whose gene is on chromosome 12q23-q24.1, and findings from linkage and association studies with the neighbouring gene of phospholipase A2 (PLA2) indicate that PLA2 may be considered as a candidate gene for affective disorders. All relevant genetic association studies, however, were conducted on bipolar patients. In the present study, the possible association between the PLA2 gene and unipolar affective disorder was examined on 321 unipolar patients and 604 controls (all personally interviewed), recruited from six countries (Belgium, Bulgaria, Croatia, Germany, Greece, and Italy) participating in the European Collaborative Project on Affective Disorders. After controlling for population group and gender, one of the eight alleles of the investigated marker (allele 7) was found to be more frequent among unipolar patients with more than three major depressive episodes than among controls (P<0.01); genotypic association was also observed, under the dominant model of genetic transmission (P<0.02). In addition, presence of allele 7 was correlated with a higher frequency of depressive episodes (P<0.02). These findings suggest that structural variations at the PLA2 gene or the chromosomal region around it may confer susceptibility for unipolar affective disorder.
AB - The co-segregation in one pedigree of bipolar affective disorder with Darier's disease whose gene is on chromosome 12q23-q24.1, and findings from linkage and association studies with the neighbouring gene of phospholipase A2 (PLA2) indicate that PLA2 may be considered as a candidate gene for affective disorders. All relevant genetic association studies, however, were conducted on bipolar patients. In the present study, the possible association between the PLA2 gene and unipolar affective disorder was examined on 321 unipolar patients and 604 controls (all personally interviewed), recruited from six countries (Belgium, Bulgaria, Croatia, Germany, Greece, and Italy) participating in the European Collaborative Project on Affective Disorders. After controlling for population group and gender, one of the eight alleles of the investigated marker (allele 7) was found to be more frequent among unipolar patients with more than three major depressive episodes than among controls (P<0.01); genotypic association was also observed, under the dominant model of genetic transmission (P<0.02). In addition, presence of allele 7 was correlated with a higher frequency of depressive episodes (P<0.02). These findings suggest that structural variations at the PLA2 gene or the chromosomal region around it may confer susceptibility for unipolar affective disorder.
KW - Chromosome 12
KW - Genetic association
KW - PLA2
KW - Phospholipase A2 gene
KW - Unipolar affective disorder
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U2 - 10.1097/00041444-200312000-00004
DO - 10.1097/00041444-200312000-00004
M3 - Article
C2 - 14639048
AN - SCOPUS:0346961692
SN - 0955-8829
VL - 13
SP - 211
EP - 220
JO - Psychiatric genetics
JF - Psychiatric genetics
IS - 4
ER -