Genetic association between the phospholipase A2 gene and unipolar affective disorder: A multicentre case-control study

George N. Papadimitriou, Dimitris G. Dikeos, Daniel Souery, Jurgen Del-Favero, Isabelle Massat, Dimitrios Avramopoulos, Sylvie Blairy, Sven Cichon, Sladjana Ivezic, Radka Kaneva, Georgia Karadima, Roberta Lilli, Vihra Milanova, Markus Nöthen, Lilijana Oruc, Marcella Rietschel, Alessandro Serretti, Christine Van Broeckhoven, Costas N. Stefanis, Julien Mendlewicz

Research output: Contribution to journalArticlepeer-review

Abstract

The co-segregation in one pedigree of bipolar affective disorder with Darier's disease whose gene is on chromosome 12q23-q24.1, and findings from linkage and association studies with the neighbouring gene of phospholipase A2 (PLA2) indicate that PLA2 may be considered as a candidate gene for affective disorders. All relevant genetic association studies, however, were conducted on bipolar patients. In the present study, the possible association between the PLA2 gene and unipolar affective disorder was examined on 321 unipolar patients and 604 controls (all personally interviewed), recruited from six countries (Belgium, Bulgaria, Croatia, Germany, Greece, and Italy) participating in the European Collaborative Project on Affective Disorders. After controlling for population group and gender, one of the eight alleles of the investigated marker (allele 7) was found to be more frequent among unipolar patients with more than three major depressive episodes than among controls (P<0.01); genotypic association was also observed, under the dominant model of genetic transmission (P<0.02). In addition, presence of allele 7 was correlated with a higher frequency of depressive episodes (P<0.02). These findings suggest that structural variations at the PLA2 gene or the chromosomal region around it may confer susceptibility for unipolar affective disorder.

Original languageEnglish (US)
Pages (from-to)211-220
Number of pages10
JournalPsychiatric genetics
Volume13
Issue number4
DOIs
StatePublished - Dec 1 2003
Externally publishedYes

Keywords

  • Chromosome 12
  • Genetic association
  • PLA2
  • Phospholipase A2 gene
  • Unipolar affective disorder

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Psychiatry and Mental health
  • Biological Psychiatry

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