Genetic Animal Models of Parkinson's Disease

Research output: Contribution to journalReview article

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder that is characterized by the degeneration of dopamine (DA) and non-DA neurons, the almost uniform presence of Lewy bodies, and motor deficits. Although the majority of PD is sporadic, specific genetic defects in rare familial cases have provided unique insights into the pathogenesis of PD. Through the creation of animal and cellular models of mutations in LRRK2 and α-synuclein, which are linked to autosomal-dominant PD, and mutations in parkin, DJ-1, and PINK1, which are responsible for autosomal-recessive PD, insight into the molecular mechanisms of this disorder are leading to new ideas about the pathogenesis of PD. In this review, we discuss the animal models for these genetic causes of PD, their limitations, and value. Moreover, we discuss future directions and potential strategies for optimization of the genetic models.

Original languageEnglish (US)
Pages (from-to)646-661
Number of pages16
JournalNeuron
Volume66
Issue number5
DOIs
StatePublished - Jun 2010

ASJC Scopus subject areas

  • Neuroscience(all)

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