Genetic and Physical Map of 11 Short Tandem Repeat Polymorphisms on Human Chromosome 6

Patricia J. Wilkie, Mihael H. Polymeropoulos, Jeffrey M. Trent, Kent W. Small, James L. Weber

Research output: Contribution to journalArticlepeer-review

Abstract

A linkage map of 11 short tandem repeat polymorphisms was constructed for human chromosome 6. The order from p to qter was F131-D6S105-D6S254-D6S251-D6S252-D6S249-(ARG1-D6S87)-D6S250-D6S255-D6S25 3. For the region spanned by the 6q markers, the male map distance was less than half the female map distance (58 and 126.3 cM, respectively). Two-point linkage analysis was also used to position the markers relative to markers in the CEPH public database. Physical mapping of these markers was completed using a somatic cell hybrid panel that contained varying segments of chromosome 6. Two of the markers mapped to the short arm of chromosome 6; the remainder were spaced over 86.5 cM of the long arm from 6q13 to 6qter. The linkage and physical maps were completely consistent.

Original languageEnglish (US)
Pages (from-to)225-227
Number of pages3
JournalGenomics
Volume15
Issue number1
DOIs
StatePublished - Jan 1993

ASJC Scopus subject areas

  • Genetics

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