Genetic and Physical Map of 11 Short Tandem Repeat Polymorphisms on Human Chromosome 6

Patricia J. Wilkie; Mihael H. Polymeropoulos; Jeffrey M. Trent; Kent W. Small; James L. Weber

doi:10.1006/geno.1993.1042

Genetic and Physical Map of 11 Short Tandem Repeat Polymorphisms on Human Chromosome 6

Patricia J. Wilkie, Mihael H. Polymeropoulos, Jeffrey M. Trent, Kent W. Small, James L. Weber

Research output: Contribution to journal › Article › peer-review

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Abstract

A linkage map of 11 short tandem repeat polymorphisms was constructed for human chromosome 6. The order from p to qter was F131-D6S105-D6S254-D6S251-D6S252-D6S249-(ARG1-D6S87)-D6S250-D6S255-D6S25 3. For the region spanned by the 6q markers, the male map distance was less than half the female map distance (58 and 126.3 cM, respectively). Two-point linkage analysis was also used to position the markers relative to markers in the CEPH public database. Physical mapping of these markers was completed using a somatic cell hybrid panel that contained varying segments of chromosome 6. Two of the markers mapped to the short arm of chromosome 6; the remainder were spaced over 86.5 cM of the long arm from 6q13 to 6qter. The linkage and physical maps were completely consistent.

Original language	English (US)
Pages (from-to)	225-227
Number of pages	3
Journal	Genomics
Volume	15
Issue number	1
DOIs	https://doi.org/10.1006/geno.1993.1042
State	Published - Jan 1993
Externally published	Yes

ASJC Scopus subject areas

Genetics

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title = "Genetic and Physical Map of 11 Short Tandem Repeat Polymorphisms on Human Chromosome 6",

abstract = "A linkage map of 11 short tandem repeat polymorphisms was constructed for human chromosome 6. The order from p to qter was F131-D6S105-D6S254-D6S251-D6S252-D6S249-(ARG1-D6S87)-D6S250-D6S255-D6S25 3. For the region spanned by the 6q markers, the male map distance was less than half the female map distance (58 and 126.3 cM, respectively). Two-point linkage analysis was also used to position the markers relative to markers in the CEPH public database. Physical mapping of these markers was completed using a somatic cell hybrid panel that contained varying segments of chromosome 6. Two of the markers mapped to the short arm of chromosome 6; the remainder were spaced over 86.5 cM of the long arm from 6q13 to 6qter. The linkage and physical maps were completely consistent.",

author = "Wilkie, {Patricia J.} and Polymeropoulos, {Mihael H.} and Trent, {Jeffrey M.} and Small, {Kent W.} and Weber, {James L.}",

year = "1993",

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T1 - Genetic and Physical Map of 11 Short Tandem Repeat Polymorphisms on Human Chromosome 6

AU - Wilkie, Patricia J.

AU - Polymeropoulos, Mihael H.

AU - Trent, Jeffrey M.

AU - Small, Kent W.

AU - Weber, James L.

PY - 1993/1

Y1 - 1993/1

N2 - A linkage map of 11 short tandem repeat polymorphisms was constructed for human chromosome 6. The order from p to qter was F131-D6S105-D6S254-D6S251-D6S252-D6S249-(ARG1-D6S87)-D6S250-D6S255-D6S25 3. For the region spanned by the 6q markers, the male map distance was less than half the female map distance (58 and 126.3 cM, respectively). Two-point linkage analysis was also used to position the markers relative to markers in the CEPH public database. Physical mapping of these markers was completed using a somatic cell hybrid panel that contained varying segments of chromosome 6. Two of the markers mapped to the short arm of chromosome 6; the remainder were spaced over 86.5 cM of the long arm from 6q13 to 6qter. The linkage and physical maps were completely consistent.

AB - A linkage map of 11 short tandem repeat polymorphisms was constructed for human chromosome 6. The order from p to qter was F131-D6S105-D6S254-D6S251-D6S252-D6S249-(ARG1-D6S87)-D6S250-D6S255-D6S25 3. For the region spanned by the 6q markers, the male map distance was less than half the female map distance (58 and 126.3 cM, respectively). Two-point linkage analysis was also used to position the markers relative to markers in the CEPH public database. Physical mapping of these markers was completed using a somatic cell hybrid panel that contained varying segments of chromosome 6. Two of the markers mapped to the short arm of chromosome 6; the remainder were spaced over 86.5 cM of the long arm from 6q13 to 6qter. The linkage and physical maps were completely consistent.

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Genetic and Physical Map of 11 Short Tandem Repeat Polymorphisms on Human Chromosome 6

Abstract

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