Genetic and Physical Map of 11 Short Tandem Repeat Polymorphisms on Human Chromosome 6

Patricia J. Wilkie, Mihael H. Polymeropoulos, Jeffrey M. Trent, Kent W. Small, James L. Weber

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Abstract

A linkage map of 11 short tandem repeat polymorphisms was constructed for human chromosome 6. The order from p to qter was F131-D6S105-D6S254-D6S251-D6S252-D6S249-(ARG1-D6S87)-D6S250-D6S255-D6S25 3. For the region spanned by the 6q markers, the male map distance was less than half the female map distance (58 and 126.3 cM, respectively). Two-point linkage analysis was also used to position the markers relative to markers in the CEPH public database. Physical mapping of these markers was completed using a somatic cell hybrid panel that contained varying segments of chromosome 6. Two of the markers mapped to the short arm of chromosome 6; the remainder were spaced over 86.5 cM of the long arm from 6q13 to 6qter. The linkage and physical maps were completely consistent.

Original languageEnglish (US)
Pages (from-to)225-227
Number of pages3
JournalGenomics
Volume15
Issue number1
DOIs
StatePublished - Jan 1993

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ASJC Scopus subject areas

  • Genetics

Cite this

Wilkie, P. J., Polymeropoulos, M. H., Trent, J. M., Small, K. W., & Weber, J. L. (1993). Genetic and Physical Map of 11 Short Tandem Repeat Polymorphisms on Human Chromosome 6. Genomics, 15(1), 225-227. https://doi.org/10.1006/geno.1993.1042