Genetische und medikamentöse einflüsse auf die funktion des präfrontalen kortex bei schizophrenen patienten

Translated title of the contribution: Genetic and pharmacological effects on prefrontal cortical function in schizophrenia

A. Heinz, D. F. Braus, B. Romero, J. Gallinat, I. Puls, G. Juckel, D. R. Weinberger

Research output: Contribution to journalReview article

Abstract

Brain imaging studies with PET, SPECT, functional magnetic resonance imaging, and spectroscopy provide evidence of prefrontal dysfunction in schizophrenia. Dysfunction of the prefrontal cortex is associated with cognitive impairment and negative symptoms. Combined multimodal imaging shows that a developmentally early disturbance of frontotemporal-limbic neuronal networks is associated with a disinhibition of subcortical dopaminergic neurotransmission. Current studies imply genetic factors in the regulation of dopaminergic neurotransmission and their effects on prefrontal cortex function. Some studies also indicate that atypical neuroleptics may at least partially improve frontal cortex function. We review the literature and discuss genotype and medication effects on frontal dysfunction in schizophrenia. Molecular brain imaging combines imaging techniques with the assessment of genotype effects and represents a powerful tool for the understanding of neuropsychiatric disorders.

Translated title of the contributionGenetic and pharmacological effects on prefrontal cortical function in schizophrenia
Original languageGerman
Pages (from-to)845-856
Number of pages12
JournalNervenarzt
Volume75
Issue number9
DOIs
StatePublished - Sep 1 2004
Externally publishedYes

Keywords

  • Atypical neuroleptics
  • COMT
  • Neurodevelopmental hypothesis
  • PFC
  • Working memory

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

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