Genetic and epigenetic events in the molecular pathology of esophageal cancer

Stefan David

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Esophageal cancer remains a severe disease with a very poor prognosis. Current research provides a valuable insight into the mechanisms that drive the progression from normal esophageal epithelium towards cancer. Key molecular alterations promoting the progression from normal mucosa to dysplastic tissue and further, to frank neoplasia represent critical factors that may be employed not only for improving our understanding of this aggressive disease, but also in early diagnostics, survival prognoses, novel therapeutic approaches and for potentially assessing the response to treatment. The current review will address they key molecular aspects of esophageal tumorigenesis, focusing on most relevant genetic alterations, on gene regulatory mechanisms and on critical cellular processes involved in the development of esophageal cancer.

Original languageEnglish (US)
Title of host publicationEsophageal Cancer
Subtitle of host publicationSymptoms, Management and Prognosis
PublisherNova Science Publishers, Inc.
Pages17-28
Number of pages12
ISBN (Electronic)9781633210851
ISBN (Print)9781633210820
StatePublished - Jul 1 2014

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    David, S. (2014). Genetic and epigenetic events in the molecular pathology of esophageal cancer. In Esophageal Cancer: Symptoms, Management and Prognosis (pp. 17-28). Nova Science Publishers, Inc..