Esophageal cancer remains a severe disease with a very poor prognosis. Current research provides a valuable insight into the mechanisms that drive the progression from normal esophageal epithelium towards cancer. Key molecular alterations promoting the progression from normal mucosa to dysplastic tissue and further, to frank neoplasia represent critical factors that may be employed not only for improving our understanding of this aggressive disease, but also in early diagnostics, survival prognoses, novel therapeutic approaches and for potentially assessing the response to treatment. The current review will address they key molecular aspects of esophageal tumorigenesis, focusing on most relevant genetic alterations, on gene regulatory mechanisms and on critical cellular processes involved in the development of esophageal cancer.
|Original language||English (US)|
|Title of host publication||Esophageal Cancer|
|Subtitle of host publication||Symptoms, Management and Prognosis|
|Publisher||Nova Science Publishers, Inc.|
|Number of pages||12|
|State||Published - Jul 1 2014|
ASJC Scopus subject areas