TY - JOUR
T1 - Genetic and environmental contributions to cholesterol and its subfractions in 11-year-old twins
T2 - The medical college of virginia twin study
AU - Bodurtha, Joann N.
AU - Chen, Chun W.
AU - Mosteller, Michael
AU - Nance, Walter E.
AU - Schicken, Richard M.
AU - Segrest, Jere
PY - 1991
Y1 - 1991
N2 - We conducted a cross-sectional analysis of the genetic and environmental contributions to the variance of lipoprotein cholesterol and its subfractions in children during early adolescence. Univariate path analysis was used to determine the relative contributions of genes, individual environment, and family environment to these measures in 233 11-year-old Caucasian twin pairs. For high density lipoprotein, high density lipoprotein2, low density lipoprotein, very low density lipoprotein, and triglycerides, a model that incorporated genes and individual environmental variation but not common environment was sufficient to explain the variation. Different magnitudes of genetic effects were seen for total cholesterol in boys and girls. High density lipoprotein3 showed different magnitudes by sex for genetic and individual environmental effect. Intermediate density lipoprotein was the only cholesterol subfraction in which shared, or common, environment was found to make a statistically significant contribution to the variation.
AB - We conducted a cross-sectional analysis of the genetic and environmental contributions to the variance of lipoprotein cholesterol and its subfractions in children during early adolescence. Univariate path analysis was used to determine the relative contributions of genes, individual environment, and family environment to these measures in 233 11-year-old Caucasian twin pairs. For high density lipoprotein, high density lipoprotein2, low density lipoprotein, very low density lipoprotein, and triglycerides, a model that incorporated genes and individual environmental variation but not common environment was sufficient to explain the variation. Different magnitudes of genetic effects were seen for total cholesterol in boys and girls. High density lipoprotein3 showed different magnitudes by sex for genetic and individual environmental effect. Intermediate density lipoprotein was the only cholesterol subfraction in which shared, or common, environment was found to make a statistically significant contribution to the variation.
KW - Cardiovascular risk
KW - Cholesterol
KW - Genetics
KW - Lipoprotein cholesterol
KW - Twins
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U2 - 10.1161/01.ATV.11.4.844
DO - 10.1161/01.ATV.11.4.844
M3 - Article
C2 - 2065038
AN - SCOPUS:0025879989
SN - 1079-5642
VL - 11
SP - 844
EP - 850
JO - Arteriosclerosis, thrombosis, and vascular biology
JF - Arteriosclerosis, thrombosis, and vascular biology
IS - 4
ER -