Genetic and environmental contributions to cholesterol and its subfractions in 11-year-old twins: The medical college of virginia twin study

Joann N. Bodurtha, Chun W. Chen, Michael Mosteller, Walter E. Nance, Richard M. Schicken, Jere Segrest

Research output: Contribution to journalArticle

Abstract

We conducted a cross-sectional analysis of the genetic and environmental contributions to the variance of lipoprotein cholesterol and its subfractions in children during early adolescence. Univariate path analysis was used to determine the relative contributions of genes, individual environment, and family environment to these measures in 233 11-year-old Caucasian twin pairs. For high density lipoprotein, high density lipoprotein2, low density lipoprotein, very low density lipoprotein, and triglycerides, a model that incorporated genes and individual environmental variation but not common environment was sufficient to explain the variation. Different magnitudes of genetic effects were seen for total cholesterol in boys and girls. High density lipoprotein3 showed different magnitudes by sex for genetic and individual environmental effect. Intermediate density lipoprotein was the only cholesterol subfraction in which shared, or common, environment was found to make a statistically significant contribution to the variation.

Original languageEnglish (US)
Pages (from-to)844-850
Number of pages7
JournalArteriosclerosis, thrombosis, and vascular biology
Volume11
Issue number4
DOIs
StatePublished - 1991
Externally publishedYes

Keywords

  • Cardiovascular risk
  • Cholesterol
  • Genetics
  • Lipoprotein cholesterol
  • Twins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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