Genetic and cellular control of spontaneous autoimmune thyroiditis in OS chickens.

L. D. Bacon, R. S. Sundick, N. R. Rose

Research output: Contribution to journalArticlepeer-review

Abstract

B-locus genotypes have been defined in Obese strain (OS) chickens that spontaneously develop autoimmune thyroiditis (SAT), and in White Leghorn Cornell C strain (CS) chickens from which the OS was selected. The B-locus influences SAT, and some possible mechanisms are discussed. Thymic abnormalities in OS, as contrasted with CB birds, are also discussed and may play a role in SAT, as may an intrinsic defect in the thyroid gland itself.

Original languageEnglish (US)
Pages (from-to)309-318
Number of pages10
JournalAdvances in experimental medicine and biology
Volume88
DOIs
StatePublished - 1977

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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