TY - JOUR
T1 - Genetic and antigenic relatedness of human and animal strains of antigenically distinct rotaviruses
AU - Eiden, Joseph
AU - Vonderfecht, Steven
AU - Theil, Kenneth
AU - Torres-Medina, Alfonso
AU - Yolken, Robert H.
N1 - Funding Information:
This work was supported in part by contract AI-52579 from the National Institute of Allergy and Infectious Diseases; by grant AM-33089 from the National Institute of Arthritis, Metabolism, and Digestive Diseases; and by the Thrasher Research Foundation, Salt Lake City, Utah.
PY - 1986
Y1 - 1986
N2 - We used nucleic-acid hybridization and enzymatic and immunofluorescence assays to examine the relatedness of human and animal strains of antigenically distinct rotaviruses (ADRVs). ADRVs isolated from rats and humans in Baltimore, Maryland, were shown to be closely related to bovine and porcine strains of group B rotavirus. A human group B rotavirus associated with epidemics of gastroenteritis in China was also found to share antigenic determinants and genome sequence homology with ADRVs passaged in rats in the United States. Closely related strains of group B rotavirus thus appear to infect human and animal populations in widely separated geographic areas.
AB - We used nucleic-acid hybridization and enzymatic and immunofluorescence assays to examine the relatedness of human and animal strains of antigenically distinct rotaviruses (ADRVs). ADRVs isolated from rats and humans in Baltimore, Maryland, were shown to be closely related to bovine and porcine strains of group B rotavirus. A human group B rotavirus associated with epidemics of gastroenteritis in China was also found to share antigenic determinants and genome sequence homology with ADRVs passaged in rats in the United States. Closely related strains of group B rotavirus thus appear to infect human and animal populations in widely separated geographic areas.
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U2 - 10.1093/infdis/154.6.972
DO - 10.1093/infdis/154.6.972
M3 - Article
C2 - 3023498
AN - SCOPUS:0023030834
SN - 0022-1899
VL - 154
SP - 972
EP - 982
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -