Genetic ancestry influences asthma susceptibility and lung function among Latinos

Maria Pino-Yanes; Neeta Thakur; Christopher R. Gignoux; Joshua M. Galanter; Lindsey A. Roth; Celeste Eng; Katherine K. Nishimura; Sam S. Oh; Hita Vora; Scott Huntsman; Elizabeth A. Nguyen; Donglei Hu; Katherine A. Drake; David V. Conti; Andres Moreno-Estrada; Karla Sandoval; Cheryl A. Winkler; Luisa N. Borrell; Fred Lurmann; Talat S. Islam; Adam Davis; Harold J. Farber; Kelley Meade; Pedro C. Avila; Denise Serebrisky; Kirsten Bibbins-Domingo; Michael A. Lenoir; Jean G. Ford; Emerita Brigino-Buenaventura; William Rodriguez-Cintron; Shannon M. Thyne; Saunak Sen; Jose R. Rodriguez-Santana; Carlos D. Bustamante; L. Keoki Williams; Frank D. Gilliland; W. James Gauderman; Rajesh Kumar; Dara G. Torgerson; Esteban G. Burchard

doi:10.1016/j.jaci.2014.07.053

Genetic ancestry influences asthma susceptibility and lung function among Latinos

Maria Pino-Yanes, Neeta Thakur, Christopher R. Gignoux, Joshua M. Galanter, Lindsey A. Roth, Celeste Eng, Katherine K. Nishimura, Sam S. Oh, Hita Vora, Scott Huntsman, Elizabeth A. Nguyen, Donglei Hu, Katherine A. Drake, David V. Conti, Andres Moreno-Estrada, Karla Sandoval, Cheryl A. Winkler, Luisa N. Borrell, Fred Lurmann, Talat S. IslamAdam Davis, Harold J. Farber, Kelley Meade, Pedro C. Avila, Denise Serebrisky, Kirsten Bibbins-Domingo, Michael A. Lenoir, Jean G. Ford, Emerita Brigino-Buenaventura, William Rodriguez-Cintron, Shannon M. Thyne, Saunak Sen, Jose R. Rodriguez-Santana, Carlos D. Bustamante, L. Keoki Williams, Frank D. Gilliland, W. James Gauderman, Rajesh Kumar, Dara G. Torgerson, Esteban G. Burchard

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

Background Childhood asthma prevalence and morbidity varies among Latinos in the United States, with Puerto Ricans having the highest and Mexicans the lowest.

Objective To determine whether genetic ancestry is associated with the odds of asthma among Latinos, and secondarily whether genetic ancestry is associated with lung function among Latino children.

Conclusion Differences in the proportions of genetic ancestry can partially explain disparities in asthma susceptibility and lung function among Latinos.

Methods We analyzed 5493 Latinos with and without asthma from 3 independent studies. For each participant, we estimated the proportion of African, European, and Native American ancestry using genome-wide data. We tested whether genetic ancestry was associated with the presence of asthma and lung function among subjects with and without asthma. Odds ratios (OR) and effect sizes were assessed for every 20% increase in each ancestry.

Results Native American ancestry was associated with lower odds of asthma (OR = 0.72, 95% CI: 0.66-0.78, P = 8.0 × 10^-15), while African ancestry was associated with higher odds of asthma (OR = 1.40, 95% CI: 1.14-1.72, P =.001). These associations were robust to adjustment for covariates related to early life exposures, air pollution, and socioeconomic status. Among children with asthma, African ancestry was associated with lower lung function, including both pre- and post-bronchodilator measures of FEV₁ (-77 ± 19 mL; P = 5.8 × 10^-5 and -83 ± 19 mL; P = 1.1 x 10^-5, respectively) and forced vital capacity (-100 ± 21 mL; P = 2.7 × 10^-6 and -107 ± 22 mL; P = 1.0 x 10^-6, respectively).

Original language	English (US)
Pages (from-to)	228-235
Number of pages	8
Journal	Journal of Allergy and Clinical Immunology
Volume	135
Issue number	1
DOIs	https://doi.org/10.1016/j.jaci.2014.07.053
State	Published - Jan 1 2015

Keywords

Genetic admixture
Hispanics
childhood asthma
minority
pulmonary function

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.jaci.2014.07.053

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Pino-Yanes, M., Thakur, N., Gignoux, C. R., Galanter, J. M., Roth, L. A., Eng, C., Nishimura, K. K., Oh, S. S., Vora, H., Huntsman, S., Nguyen, E. A., Hu, D., Drake, K. A., Conti, D. V., Moreno-Estrada, A., Sandoval, K., Winkler, C. A., Borrell, L. N., Lurmann, F., ... Burchard, E. G. (2015). Genetic ancestry influences asthma susceptibility and lung function among Latinos. Journal of Allergy and Clinical Immunology, 135(1), 228-235. https://doi.org/10.1016/j.jaci.2014.07.053

Pino-Yanes, M, Thakur, N, Gignoux, CR, Galanter, JM, Roth, LA, Eng, C, Nishimura, KK, Oh, SS, Vora, H, Huntsman, S, Nguyen, EA, Hu, D, Drake, KA, Conti, DV, Moreno-Estrada, A, Sandoval, K, Winkler, CA, Borrell, LN, Lurmann, F, Islam, TS, Davis, A, Farber, HJ, Meade, K, Avila, PC, Serebrisky, D, Bibbins-Domingo, K, Lenoir, MA, Ford, JG, Brigino-Buenaventura, E, Rodriguez-Cintron, W, Thyne, SM, Sen, S, Rodriguez-Santana, JR, Bustamante, CD, Williams, LK, Gilliland, FD, Gauderman, WJ, Kumar, R, Torgerson, DG & Burchard, EG 2015, 'Genetic ancestry influences asthma susceptibility and lung function among Latinos', Journal of Allergy and Clinical Immunology, vol. 135, no. 1, pp. 228-235. https://doi.org/10.1016/j.jaci.2014.07.053

@article{de0b308c3ff94ea99fbd2f69f2430798,

title = "Genetic ancestry influences asthma susceptibility and lung function among Latinos",

abstract = "Background Childhood asthma prevalence and morbidity varies among Latinos in the United States, with Puerto Ricans having the highest and Mexicans the lowest.Objective To determine whether genetic ancestry is associated with the odds of asthma among Latinos, and secondarily whether genetic ancestry is associated with lung function among Latino children.Conclusion Differences in the proportions of genetic ancestry can partially explain disparities in asthma susceptibility and lung function among Latinos.Methods We analyzed 5493 Latinos with and without asthma from 3 independent studies. For each participant, we estimated the proportion of African, European, and Native American ancestry using genome-wide data. We tested whether genetic ancestry was associated with the presence of asthma and lung function among subjects with and without asthma. Odds ratios (OR) and effect sizes were assessed for every 20% increase in each ancestry.Results Native American ancestry was associated with lower odds of asthma (OR = 0.72, 95% CI: 0.66-0.78, P = 8.0 × 10-15), while African ancestry was associated with higher odds of asthma (OR = 1.40, 95% CI: 1.14-1.72, P =.001). These associations were robust to adjustment for covariates related to early life exposures, air pollution, and socioeconomic status. Among children with asthma, African ancestry was associated with lower lung function, including both pre- and post-bronchodilator measures of FEV1 (-77 ± 19 mL; P = 5.8 × 10-5 and -83 ± 19 mL; P = 1.1 x 10-5, respectively) and forced vital capacity (-100 ± 21 mL; P = 2.7 × 10-6 and -107 ± 22 mL; P = 1.0 x 10-6, respectively).",

keywords = "Genetic admixture, Hispanics, childhood asthma, minority, pulmonary function",

author = "Maria Pino-Yanes and Neeta Thakur and Gignoux, {Christopher R.} and Galanter, {Joshua M.} and Roth, {Lindsey A.} and Celeste Eng and Nishimura, {Katherine K.} and Oh, {Sam S.} and Hita Vora and Scott Huntsman and Nguyen, {Elizabeth A.} and Donglei Hu and Drake, {Katherine A.} and Conti, {David V.} and Andres Moreno-Estrada and Karla Sandoval and Winkler, {Cheryl A.} and Borrell, {Luisa N.} and Fred Lurmann and Islam, {Talat S.} and Adam Davis and Farber, {Harold J.} and Kelley Meade and Avila, {Pedro C.} and Denise Serebrisky and Kirsten Bibbins-Domingo and Lenoir, {Michael A.} and Ford, {Jean G.} and Emerita Brigino-Buenaventura and William Rodriguez-Cintron and Thyne, {Shannon M.} and Saunak Sen and Rodriguez-Santana, {Jose R.} and Bustamante, {Carlos D.} and Williams, {L. Keoki} and Gilliland, {Frank D.} and Gauderman, {W. James} and Rajesh Kumar and Torgerson, {Dara G.} and Burchard, {Esteban G.}",

note = "Publisher Copyright: {\textcopyright} 2014 American Academy of Allergy, Asthma & Immunology.",

year = "2015",

month = jan,

day = "1",

doi = "10.1016/j.jaci.2014.07.053",

language = "English (US)",

volume = "135",

pages = "228--235",

journal = "Journal of Allergy and Clinical Immunology",

issn = "0091-6749",

publisher = "Mosby Inc.",

number = "1",

}

TY - JOUR

T1 - Genetic ancestry influences asthma susceptibility and lung function among Latinos

AU - Pino-Yanes, Maria

AU - Thakur, Neeta

AU - Gignoux, Christopher R.

AU - Galanter, Joshua M.

AU - Roth, Lindsey A.

AU - Eng, Celeste

AU - Nishimura, Katherine K.

AU - Oh, Sam S.

AU - Vora, Hita

AU - Huntsman, Scott

AU - Nguyen, Elizabeth A.

AU - Hu, Donglei

AU - Drake, Katherine A.

AU - Conti, David V.

AU - Moreno-Estrada, Andres

AU - Sandoval, Karla

AU - Winkler, Cheryl A.

AU - Borrell, Luisa N.

AU - Lurmann, Fred

AU - Islam, Talat S.

AU - Davis, Adam

AU - Farber, Harold J.

AU - Meade, Kelley

AU - Avila, Pedro C.

AU - Serebrisky, Denise

AU - Bibbins-Domingo, Kirsten

AU - Lenoir, Michael A.

AU - Ford, Jean G.

AU - Brigino-Buenaventura, Emerita

AU - Rodriguez-Cintron, William

AU - Thyne, Shannon M.

AU - Sen, Saunak

AU - Rodriguez-Santana, Jose R.

AU - Bustamante, Carlos D.

AU - Williams, L. Keoki

AU - Gilliland, Frank D.

AU - Gauderman, W. James

AU - Kumar, Rajesh

AU - Torgerson, Dara G.

AU - Burchard, Esteban G.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background Childhood asthma prevalence and morbidity varies among Latinos in the United States, with Puerto Ricans having the highest and Mexicans the lowest.Objective To determine whether genetic ancestry is associated with the odds of asthma among Latinos, and secondarily whether genetic ancestry is associated with lung function among Latino children.Conclusion Differences in the proportions of genetic ancestry can partially explain disparities in asthma susceptibility and lung function among Latinos.Methods We analyzed 5493 Latinos with and without asthma from 3 independent studies. For each participant, we estimated the proportion of African, European, and Native American ancestry using genome-wide data. We tested whether genetic ancestry was associated with the presence of asthma and lung function among subjects with and without asthma. Odds ratios (OR) and effect sizes were assessed for every 20% increase in each ancestry.Results Native American ancestry was associated with lower odds of asthma (OR = 0.72, 95% CI: 0.66-0.78, P = 8.0 × 10-15), while African ancestry was associated with higher odds of asthma (OR = 1.40, 95% CI: 1.14-1.72, P =.001). These associations were robust to adjustment for covariates related to early life exposures, air pollution, and socioeconomic status. Among children with asthma, African ancestry was associated with lower lung function, including both pre- and post-bronchodilator measures of FEV1 (-77 ± 19 mL; P = 5.8 × 10-5 and -83 ± 19 mL; P = 1.1 x 10-5, respectively) and forced vital capacity (-100 ± 21 mL; P = 2.7 × 10-6 and -107 ± 22 mL; P = 1.0 x 10-6, respectively).

AB - Background Childhood asthma prevalence and morbidity varies among Latinos in the United States, with Puerto Ricans having the highest and Mexicans the lowest.Objective To determine whether genetic ancestry is associated with the odds of asthma among Latinos, and secondarily whether genetic ancestry is associated with lung function among Latino children.Conclusion Differences in the proportions of genetic ancestry can partially explain disparities in asthma susceptibility and lung function among Latinos.Methods We analyzed 5493 Latinos with and without asthma from 3 independent studies. For each participant, we estimated the proportion of African, European, and Native American ancestry using genome-wide data. We tested whether genetic ancestry was associated with the presence of asthma and lung function among subjects with and without asthma. Odds ratios (OR) and effect sizes were assessed for every 20% increase in each ancestry.Results Native American ancestry was associated with lower odds of asthma (OR = 0.72, 95% CI: 0.66-0.78, P = 8.0 × 10-15), while African ancestry was associated with higher odds of asthma (OR = 1.40, 95% CI: 1.14-1.72, P =.001). These associations were robust to adjustment for covariates related to early life exposures, air pollution, and socioeconomic status. Among children with asthma, African ancestry was associated with lower lung function, including both pre- and post-bronchodilator measures of FEV1 (-77 ± 19 mL; P = 5.8 × 10-5 and -83 ± 19 mL; P = 1.1 x 10-5, respectively) and forced vital capacity (-100 ± 21 mL; P = 2.7 × 10-6 and -107 ± 22 mL; P = 1.0 x 10-6, respectively).

KW - Genetic admixture

KW - Hispanics

KW - childhood asthma

KW - minority

KW - pulmonary function

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DO - 10.1016/j.jaci.2014.07.053

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SN - 0091-6749

VL - 135

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EP - 235

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

IS - 1

ER -

Genetic ancestry influences asthma susceptibility and lung function among Latinos

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