Genetic ancestry influences asthma susceptibility and lung function among Latinos

Maria Pino-Yanes, Neeta Thakur, Christopher R. Gignoux, Joshua M. Galanter, Lindsey A. Roth, Celeste Eng, Katherine K. Nishimura, Sam S. Oh, Hita Vora, Scott Huntsman, Elizabeth A. Nguyen, Donglei Hu, Katherine A. Drake, David V. Conti, Andres Moreno-Estrada, Karla Sandoval, Cheryl A. Winkler, Luisa N. Borrell, Fred Lurmann, Talat S. IslamAdam Davis, Harold J. Farber, Kelley Meade, Pedro C. Avila, Denise Serebrisky, Kirsten Bibbins-Domingo, Michael A. Lenoir, Jean G. Ford, Emerita Brigino-Buenaventura, William Rodriguez-Cintron, Shannon M. Thyne, Saunak Sen, Jose R. Rodriguez-Santana, Carlos D. Bustamante, L. Keoki Williams, Frank D. Gilliland, W. James Gauderman, Rajesh Kumar, Dara G. Torgerson, Esteban G. Burchard

Research output: Contribution to journalArticle

Abstract

Background Childhood asthma prevalence and morbidity varies among Latinos in the United States, with Puerto Ricans having the highest and Mexicans the lowest.

Objective To determine whether genetic ancestry is associated with the odds of asthma among Latinos, and secondarily whether genetic ancestry is associated with lung function among Latino children.

Methods We analyzed 5493 Latinos with and without asthma from 3 independent studies. For each participant, we estimated the proportion of African, European, and Native American ancestry using genome-wide data. We tested whether genetic ancestry was associated with the presence of asthma and lung function among subjects with and without asthma. Odds ratios (OR) and effect sizes were assessed for every 20% increase in each ancestry.

Results Native American ancestry was associated with lower odds of asthma (OR = 0.72, 95% CI: 0.66-0.78, P = 8.0 × 10-15), while African ancestry was associated with higher odds of asthma (OR = 1.40, 95% CI: 1.14-1.72, P =.001). These associations were robust to adjustment for covariates related to early life exposures, air pollution, and socioeconomic status. Among children with asthma, African ancestry was associated with lower lung function, including both pre- and post-bronchodilator measures of FEV1 (-77 ± 19 mL; P = 5.8 × 10-5 and -83 ± 19 mL; P = 1.1 x 10-5, respectively) and forced vital capacity (-100 ± 21 mL; P = 2.7 × 10-6 and -107 ± 22 mL; P = 1.0 x 10-6, respectively).

Conclusion Differences in the proportions of genetic ancestry can partially explain disparities in asthma susceptibility and lung function among Latinos.

Original languageEnglish (US)
Pages (from-to)228-235
Number of pages8
JournalThe Journal of Allergy and Clinical Immunology
Volume135
Issue number1
DOIs
StatePublished - Jan 1 2015

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Hispanic Americans
Asthma
Lung
North American Indians
Bronchodilator Agents
Odds Ratio
Vital Capacity
Air Pollution
Social Class
African Americans
Genome
Morbidity

Keywords

  • childhood asthma
  • Genetic admixture
  • Hispanics
  • minority
  • pulmonary function

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Pino-Yanes, M., Thakur, N., Gignoux, C. R., Galanter, J. M., Roth, L. A., Eng, C., ... Burchard, E. G. (2015). Genetic ancestry influences asthma susceptibility and lung function among Latinos. The Journal of Allergy and Clinical Immunology, 135(1), 228-235. https://doi.org/10.1016/j.jaci.2014.07.053

Genetic ancestry influences asthma susceptibility and lung function among Latinos. / Pino-Yanes, Maria; Thakur, Neeta; Gignoux, Christopher R.; Galanter, Joshua M.; Roth, Lindsey A.; Eng, Celeste; Nishimura, Katherine K.; Oh, Sam S.; Vora, Hita; Huntsman, Scott; Nguyen, Elizabeth A.; Hu, Donglei; Drake, Katherine A.; Conti, David V.; Moreno-Estrada, Andres; Sandoval, Karla; Winkler, Cheryl A.; Borrell, Luisa N.; Lurmann, Fred; Islam, Talat S.; Davis, Adam; Farber, Harold J.; Meade, Kelley; Avila, Pedro C.; Serebrisky, Denise; Bibbins-Domingo, Kirsten; Lenoir, Michael A.; Ford, Jean G.; Brigino-Buenaventura, Emerita; Rodriguez-Cintron, William; Thyne, Shannon M.; Sen, Saunak; Rodriguez-Santana, Jose R.; Bustamante, Carlos D.; Williams, L. Keoki; Gilliland, Frank D.; Gauderman, W. James; Kumar, Rajesh; Torgerson, Dara G.; Burchard, Esteban G.

In: The Journal of Allergy and Clinical Immunology, Vol. 135, No. 1, 01.01.2015, p. 228-235.

Research output: Contribution to journalArticle

Pino-Yanes, M, Thakur, N, Gignoux, CR, Galanter, JM, Roth, LA, Eng, C, Nishimura, KK, Oh, SS, Vora, H, Huntsman, S, Nguyen, EA, Hu, D, Drake, KA, Conti, DV, Moreno-Estrada, A, Sandoval, K, Winkler, CA, Borrell, LN, Lurmann, F, Islam, TS, Davis, A, Farber, HJ, Meade, K, Avila, PC, Serebrisky, D, Bibbins-Domingo, K, Lenoir, MA, Ford, JG, Brigino-Buenaventura, E, Rodriguez-Cintron, W, Thyne, SM, Sen, S, Rodriguez-Santana, JR, Bustamante, CD, Williams, LK, Gilliland, FD, Gauderman, WJ, Kumar, R, Torgerson, DG & Burchard, EG 2015, 'Genetic ancestry influences asthma susceptibility and lung function among Latinos', The Journal of Allergy and Clinical Immunology, vol. 135, no. 1, pp. 228-235. https://doi.org/10.1016/j.jaci.2014.07.053
Pino-Yanes, Maria ; Thakur, Neeta ; Gignoux, Christopher R. ; Galanter, Joshua M. ; Roth, Lindsey A. ; Eng, Celeste ; Nishimura, Katherine K. ; Oh, Sam S. ; Vora, Hita ; Huntsman, Scott ; Nguyen, Elizabeth A. ; Hu, Donglei ; Drake, Katherine A. ; Conti, David V. ; Moreno-Estrada, Andres ; Sandoval, Karla ; Winkler, Cheryl A. ; Borrell, Luisa N. ; Lurmann, Fred ; Islam, Talat S. ; Davis, Adam ; Farber, Harold J. ; Meade, Kelley ; Avila, Pedro C. ; Serebrisky, Denise ; Bibbins-Domingo, Kirsten ; Lenoir, Michael A. ; Ford, Jean G. ; Brigino-Buenaventura, Emerita ; Rodriguez-Cintron, William ; Thyne, Shannon M. ; Sen, Saunak ; Rodriguez-Santana, Jose R. ; Bustamante, Carlos D. ; Williams, L. Keoki ; Gilliland, Frank D. ; Gauderman, W. James ; Kumar, Rajesh ; Torgerson, Dara G. ; Burchard, Esteban G. / Genetic ancestry influences asthma susceptibility and lung function among Latinos. In: The Journal of Allergy and Clinical Immunology. 2015 ; Vol. 135, No. 1. pp. 228-235.
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title = "Genetic ancestry influences asthma susceptibility and lung function among Latinos",
abstract = "Background Childhood asthma prevalence and morbidity varies among Latinos in the United States, with Puerto Ricans having the highest and Mexicans the lowest.Objective To determine whether genetic ancestry is associated with the odds of asthma among Latinos, and secondarily whether genetic ancestry is associated with lung function among Latino children.Methods We analyzed 5493 Latinos with and without asthma from 3 independent studies. For each participant, we estimated the proportion of African, European, and Native American ancestry using genome-wide data. We tested whether genetic ancestry was associated with the presence of asthma and lung function among subjects with and without asthma. Odds ratios (OR) and effect sizes were assessed for every 20{\%} increase in each ancestry.Results Native American ancestry was associated with lower odds of asthma (OR = 0.72, 95{\%} CI: 0.66-0.78, P = 8.0 × 10-15), while African ancestry was associated with higher odds of asthma (OR = 1.40, 95{\%} CI: 1.14-1.72, P =.001). These associations were robust to adjustment for covariates related to early life exposures, air pollution, and socioeconomic status. Among children with asthma, African ancestry was associated with lower lung function, including both pre- and post-bronchodilator measures of FEV1 (-77 ± 19 mL; P = 5.8 × 10-5 and -83 ± 19 mL; P = 1.1 x 10-5, respectively) and forced vital capacity (-100 ± 21 mL; P = 2.7 × 10-6 and -107 ± 22 mL; P = 1.0 x 10-6, respectively).Conclusion Differences in the proportions of genetic ancestry can partially explain disparities in asthma susceptibility and lung function among Latinos.",
keywords = "childhood asthma, Genetic admixture, Hispanics, minority, pulmonary function",
author = "Maria Pino-Yanes and Neeta Thakur and Gignoux, {Christopher R.} and Galanter, {Joshua M.} and Roth, {Lindsey A.} and Celeste Eng and Nishimura, {Katherine K.} and Oh, {Sam S.} and Hita Vora and Scott Huntsman and Nguyen, {Elizabeth A.} and Donglei Hu and Drake, {Katherine A.} and Conti, {David V.} and Andres Moreno-Estrada and Karla Sandoval and Winkler, {Cheryl A.} and Borrell, {Luisa N.} and Fred Lurmann and Islam, {Talat S.} and Adam Davis and Farber, {Harold J.} and Kelley Meade and Avila, {Pedro C.} and Denise Serebrisky and Kirsten Bibbins-Domingo and Lenoir, {Michael A.} and Ford, {Jean G.} and Emerita Brigino-Buenaventura and William Rodriguez-Cintron and Thyne, {Shannon M.} and Saunak Sen and Rodriguez-Santana, {Jose R.} and Bustamante, {Carlos D.} and Williams, {L. Keoki} and Gilliland, {Frank D.} and Gauderman, {W. James} and Rajesh Kumar and Torgerson, {Dara G.} and Burchard, {Esteban G.}",
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TY - JOUR

T1 - Genetic ancestry influences asthma susceptibility and lung function among Latinos

AU - Pino-Yanes, Maria

AU - Thakur, Neeta

AU - Gignoux, Christopher R.

AU - Galanter, Joshua M.

AU - Roth, Lindsey A.

AU - Eng, Celeste

AU - Nishimura, Katherine K.

AU - Oh, Sam S.

AU - Vora, Hita

AU - Huntsman, Scott

AU - Nguyen, Elizabeth A.

AU - Hu, Donglei

AU - Drake, Katherine A.

AU - Conti, David V.

AU - Moreno-Estrada, Andres

AU - Sandoval, Karla

AU - Winkler, Cheryl A.

AU - Borrell, Luisa N.

AU - Lurmann, Fred

AU - Islam, Talat S.

AU - Davis, Adam

AU - Farber, Harold J.

AU - Meade, Kelley

AU - Avila, Pedro C.

AU - Serebrisky, Denise

AU - Bibbins-Domingo, Kirsten

AU - Lenoir, Michael A.

AU - Ford, Jean G.

AU - Brigino-Buenaventura, Emerita

AU - Rodriguez-Cintron, William

AU - Thyne, Shannon M.

AU - Sen, Saunak

AU - Rodriguez-Santana, Jose R.

AU - Bustamante, Carlos D.

AU - Williams, L. Keoki

AU - Gilliland, Frank D.

AU - Gauderman, W. James

AU - Kumar, Rajesh

AU - Torgerson, Dara G.

AU - Burchard, Esteban G.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background Childhood asthma prevalence and morbidity varies among Latinos in the United States, with Puerto Ricans having the highest and Mexicans the lowest.Objective To determine whether genetic ancestry is associated with the odds of asthma among Latinos, and secondarily whether genetic ancestry is associated with lung function among Latino children.Methods We analyzed 5493 Latinos with and without asthma from 3 independent studies. For each participant, we estimated the proportion of African, European, and Native American ancestry using genome-wide data. We tested whether genetic ancestry was associated with the presence of asthma and lung function among subjects with and without asthma. Odds ratios (OR) and effect sizes were assessed for every 20% increase in each ancestry.Results Native American ancestry was associated with lower odds of asthma (OR = 0.72, 95% CI: 0.66-0.78, P = 8.0 × 10-15), while African ancestry was associated with higher odds of asthma (OR = 1.40, 95% CI: 1.14-1.72, P =.001). These associations were robust to adjustment for covariates related to early life exposures, air pollution, and socioeconomic status. Among children with asthma, African ancestry was associated with lower lung function, including both pre- and post-bronchodilator measures of FEV1 (-77 ± 19 mL; P = 5.8 × 10-5 and -83 ± 19 mL; P = 1.1 x 10-5, respectively) and forced vital capacity (-100 ± 21 mL; P = 2.7 × 10-6 and -107 ± 22 mL; P = 1.0 x 10-6, respectively).Conclusion Differences in the proportions of genetic ancestry can partially explain disparities in asthma susceptibility and lung function among Latinos.

AB - Background Childhood asthma prevalence and morbidity varies among Latinos in the United States, with Puerto Ricans having the highest and Mexicans the lowest.Objective To determine whether genetic ancestry is associated with the odds of asthma among Latinos, and secondarily whether genetic ancestry is associated with lung function among Latino children.Methods We analyzed 5493 Latinos with and without asthma from 3 independent studies. For each participant, we estimated the proportion of African, European, and Native American ancestry using genome-wide data. We tested whether genetic ancestry was associated with the presence of asthma and lung function among subjects with and without asthma. Odds ratios (OR) and effect sizes were assessed for every 20% increase in each ancestry.Results Native American ancestry was associated with lower odds of asthma (OR = 0.72, 95% CI: 0.66-0.78, P = 8.0 × 10-15), while African ancestry was associated with higher odds of asthma (OR = 1.40, 95% CI: 1.14-1.72, P =.001). These associations were robust to adjustment for covariates related to early life exposures, air pollution, and socioeconomic status. Among children with asthma, African ancestry was associated with lower lung function, including both pre- and post-bronchodilator measures of FEV1 (-77 ± 19 mL; P = 5.8 × 10-5 and -83 ± 19 mL; P = 1.1 x 10-5, respectively) and forced vital capacity (-100 ± 21 mL; P = 2.7 × 10-6 and -107 ± 22 mL; P = 1.0 x 10-6, respectively).Conclusion Differences in the proportions of genetic ancestry can partially explain disparities in asthma susceptibility and lung function among Latinos.

KW - childhood asthma

KW - Genetic admixture

KW - Hispanics

KW - minority

KW - pulmonary function

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DO - 10.1016/j.jaci.2014.07.053

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JO - Journal of Allergy and Clinical Immunology

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