Genetic analysis of the NZB contribution to lupus-like autoimmune disease in (NZB x NZW)F1 mice

Charles G. Drake, Susan K. Babcock, E. D. Palmer, Brian L. Kotzin

Research output: Contribution to journalArticlepeer-review

Abstract

Lupus-like autoimmunity in (NZB x NZW)F1 mice is frequently marked by the development of a severe and fatal renal disease. Genes from both NZB and NZW parents are required for the full expression of disease. We applied a mapping technique based on polymorphism in simple sequence repeats to the analysis of (NZB x NZW)F1 x NZW backcross mice to determine the NZB genetic contribution to disease. The results show that a single NZB locus or tightly linked group of loci on the distal part of chromosome 4 provides the strongest association with renal disease and death. This locus, designated here as nba-1 (New Zealand Black autoimmunity), lies distal to the locus elp-1, 60-70 centimorgans from the centromere. It is of interest that a gene encoding a receptor for tumor necrosis factor maps to the vicinity of this disease- associated gene.

Original languageEnglish (US)
Pages (from-to)4062-4066
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume91
Issue number9
StatePublished - Apr 26 1994
Externally publishedYes

Keywords

  • linkage
  • New Zealand mice
  • systemic lupus erythematosus

ASJC Scopus subject areas

  • Genetics
  • General

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