Genetic analysis of the (CTG)n NOTCH4 polymorphism in 65 multiplex bipolar pedigrees

T. Swift-Scanlan, T. H. Lan, M. D. Fallin, J. M. Coughlin, J. B. Potash, J. R. DePaulo, M. G. McInnis

Research output: Contribution to journalArticlepeer-review

Abstract

A strong genetic association between the NOTCH4 locus on chromosome 6 and schizophrenia was recently reported. Based on the data suggesting overlapping susceptibility for schizophrenia and bipolar disorder, we genotyped the polymorphic (CTG)n encoding polyleucine repeat in exon 1 of NOTCH4 in 65 pedigrees ascertained for a genetic linkage study of bipolar disorder. In addition, we analyzed a subset of our pedigrees with psychotic features at this locus. We failed to find any association between the (CTG)n NOTCH4 polymorphism and either the bipolar or the psychotic bipolar phenotype in our 65 pedigrees.

Original languageEnglish (US)
Pages (from-to)43-47
Number of pages5
JournalPsychiatric genetics
Volume12
Issue number1
DOIs
StatePublished - 2002

Keywords

  • Association study
  • Bipolar disorder
  • Complex disease
  • Multifactorial disorder
  • Trinucleotide repeat

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Psychiatry and Mental health
  • Biological Psychiatry

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