Genetic analysis of the (CTG)n NOTCH4 polymorphism in 65 multiplex bipolar pedigrees

T. Swift-Scanlan; T. H. Lan; M. D. Fallin; J. M. Coughlin; J. B. Potash; J. R. DePaulo; Melvin Mcinnis

doi:10.1097/00041444-200203000-00006

Genetic analysis of the (CTG)_n NOTCH4 polymorphism in 65 multiplex bipolar pedigrees

T. Swift-Scanlan, T. H. Lan, M. D. Fallin, J. M. Coughlin, J. B. Potash, J. R. DePaulo, Melvin Mcinnis

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A strong genetic association between the NOTCH4 locus on chromosome 6 and schizophrenia was recently reported. Based on the data suggesting overlapping susceptibility for schizophrenia and bipolar disorder, we genotyped the polymorphic (CTG)_n encoding polyleucine repeat in exon 1 of NOTCH4 in 65 pedigrees ascertained for a genetic linkage study of bipolar disorder. In addition, we analyzed a subset of our pedigrees with psychotic features at this locus. We failed to find any association between the (CTG)_n NOTCH4 polymorphism and either the bipolar or the psychotic bipolar phenotype in our 65 pedigrees.

Original language	English (US)
Pages (from-to)	43-47
Number of pages	5
Journal	Psychiatric genetics
Volume	12
Issue number	1
DOIs	https://doi.org/10.1097/00041444-200203000-00006
State	Published - 2002

Keywords

Association study
Bipolar disorder
Complex disease
Multifactorial disorder
Trinucleotide repeat

ASJC Scopus subject areas

Genetics
Genetics(clinical)
Psychiatry and Mental health
Biological Psychiatry

Access to Document

10.1097/00041444-200203000-00006

Cite this

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title = "Genetic analysis of the (CTG)n NOTCH4 polymorphism in 65 multiplex bipolar pedigrees",

abstract = "A strong genetic association between the NOTCH4 locus on chromosome 6 and schizophrenia was recently reported. Based on the data suggesting overlapping susceptibility for schizophrenia and bipolar disorder, we genotyped the polymorphic (CTG)n encoding polyleucine repeat in exon 1 of NOTCH4 in 65 pedigrees ascertained for a genetic linkage study of bipolar disorder. In addition, we analyzed a subset of our pedigrees with psychotic features at this locus. We failed to find any association between the (CTG)n NOTCH4 polymorphism and either the bipolar or the psychotic bipolar phenotype in our 65 pedigrees.",

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T1 - Genetic analysis of the (CTG)n NOTCH4 polymorphism in 65 multiplex bipolar pedigrees

AU - Swift-Scanlan, T.

AU - Lan, T. H.

AU - Fallin, M. D.

AU - Coughlin, J. M.

AU - Potash, J. B.

AU - DePaulo, J. R.

AU - Mcinnis, Melvin

PY - 2002

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AB - A strong genetic association between the NOTCH4 locus on chromosome 6 and schizophrenia was recently reported. Based on the data suggesting overlapping susceptibility for schizophrenia and bipolar disorder, we genotyped the polymorphic (CTG)n encoding polyleucine repeat in exon 1 of NOTCH4 in 65 pedigrees ascertained for a genetic linkage study of bipolar disorder. In addition, we analyzed a subset of our pedigrees with psychotic features at this locus. We failed to find any association between the (CTG)n NOTCH4 polymorphism and either the bipolar or the psychotic bipolar phenotype in our 65 pedigrees.

KW - Association study

KW - Bipolar disorder

KW - Complex disease

KW - Multifactorial disorder

KW - Trinucleotide repeat

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