Genetic analysis of eight population groups living in Taiwan using a 13 X-chromosomal STR loci multiplex system

Hsiao Lin Hwa, James Chun I Lee, Yih Yuan Chang, Hsiang Yi Yin, Ya Hui Chen, Li Hui Tseng, Yi Ning Su, Tsang Ming Ko

Research output: Contribution to journalArticlepeer-review

Abstract

A 13 X-chromosomal short tandem repeat (STR) multiplex system (DXS6807, DXS8378, DSX9902, DXS7132, DXS9898, DXS6809, DXS6789, DXS7424, DXS101, GATA172D05, HPRTB, DXS8377, and DXS7423) was tested on 1,037 DNA samples from eight population groups currently living in Taiwan. Different distributions of the allelic frequencies in different populations were presented. DXS8377 and DXS101 were the two most polymorphic loci in these eight populations, whereas DXS7423 was the least informative marker in most of the populations studied. The genetic distances between the populations and the constructed phylogenetic tree revealed a long genetic distance between Asian and Caucasian populations as well as isolation of the Tao population. The phylogenetic tree grouped populations into clusters compatible with their ethnogeographic relationships. This 13 X-chromosomal short tandem repeat multiplex system offers a considerable number of polymorphic patterns in different populations. This system can be useful in forensic identification casework and ethnogeographic research.

Original languageEnglish (US)
Pages (from-to)33-37
Number of pages5
JournalInternational Journal of Legal Medicine
Volume125
Issue number1
DOIs
StatePublished - Jan 2011
Externally publishedYes

Keywords

  • Forensic identification
  • Genetic distance
  • Multiplex PCR
  • Phylogenetic tree
  • Short tandem repeat
  • X chromosome

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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