Genetic alterations in salivary gland cancers

Linda X. Yin, Patrick K. Ha

Research output: Contribution to journalReview articlepeer-review

Abstract

Salivary gland cancers are an incredibly heterogeneous group of tumors that include 24 histologically distinct tumor types. The use of new genetic methods has paved the way for promising advancements in our understanding of the molecular biology underlying each type of tumor. The objective of this review was to highlight common oncogenes, tumor suppressor genes, and cytogenetic and epigenetic changes associated with the most common tumor types: mucoepidermoid carcinoma, adenoid cystic carcinoma, salivary duct carcinoma, mammary analogue secretory carcinoma, hyalinizing clear cell carcinoma, carcinoma ex pleomorphic adenoma, and acinic cell carcinoma. Recent insights into the pathogenesis of each cancer subtype have helped better define and classify these tumors. Further research in salivary gland cancers should focus on determining the key genes involved in the tumorigenesis of each distinct malignancy and identifying individualized chemotherapies directed at these targets.

Original languageEnglish (US)
Pages (from-to)1822-1831
Number of pages10
JournalCancer
Volume122
Issue number12
DOIs
StatePublished - Jun 15 2016

Keywords

  • acinic cell carcinoma
  • adenoid cystic carcinoma
  • cytogenetics
  • epigenetics
  • genetics
  • hyalinizing clear cell carcinoma
  • mammary analogue secretory carcinoma
  • mucoepidermoid carcinoma
  • salivary duct carcinoma
  • salivary gland cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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