Abstract
Genes with triplet repeats are responsible for an expanding number of human diseases The function of triplet repeats in the human genome is still unknown, but several different triplets are quite common. Many triplet repeat containing genes appear to have a role in development. Expansion of triplet repeats can cause disease by several different mechanisms, including both loss of function and gain of function properties. The diseases in which CAG codes for glutamine in disease gene protein products are all neurodegenerative diseases, possibly involving interactions with other proteins. It is likely that additional triplet repeat diseases will be identified in the future.
| Original language | English (US) |
|---|---|
| Pages (from-to) | A1014 |
| Journal | FASEB Journal |
| Volume | 11 |
| Issue number | 9 |
| State | Published - 1997 |
ASJC Scopus subject areas
- Biotechnology
- Biochemistry
- Molecular Biology
- Genetics