TY - JOUR
T1 - Genes that drive invasion and migration in Drosophila
AU - Starz-Gaiano, Michelle
AU - Montell, Denise J.
PY - 2004/2
Y1 - 2004/2
N2 - Successful cell migration depends on the careful regulation of the timing of movement, the guidance of motile cells, and cytoskeletal and adhesive changes within the cells. This review focuses on genes that act cell-autonomously to promote these aspects of cell migration in Drosophila. We discuss recent advances in understanding the migration of the ovarian border cells, embryonic blood cells, primordial germ cells, somatic gonadal precursors, and tracheal cells. Comparison of genes that regulate these processes to those that promote tumorigenesis and metastasis in mammals demonstrates that studies in fruit flies are uncovering new genes highly relevant to cancer biology.
AB - Successful cell migration depends on the careful regulation of the timing of movement, the guidance of motile cells, and cytoskeletal and adhesive changes within the cells. This review focuses on genes that act cell-autonomously to promote these aspects of cell migration in Drosophila. We discuss recent advances in understanding the migration of the ovarian border cells, embryonic blood cells, primordial germ cells, somatic gonadal precursors, and tracheal cells. Comparison of genes that regulate these processes to those that promote tumorigenesis and metastasis in mammals demonstrates that studies in fruit flies are uncovering new genes highly relevant to cancer biology.
UR - http://www.scopus.com/inward/record.url?scp=0842346273&partnerID=8YFLogxK
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U2 - 10.1016/j.gde.2003.12.001
DO - 10.1016/j.gde.2003.12.001
M3 - Review article
C2 - 15108810
AN - SCOPUS:0842346273
VL - 14
SP - 86
EP - 91
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
SN - 0959-437X
IS - 1
ER -