Genes that drive invasion and migration in Drosophila

Michelle Starz-Gaiano, Denise J. Montell

Research output: Contribution to journalReview articlepeer-review

Abstract

Successful cell migration depends on the careful regulation of the timing of movement, the guidance of motile cells, and cytoskeletal and adhesive changes within the cells. This review focuses on genes that act cell-autonomously to promote these aspects of cell migration in Drosophila. We discuss recent advances in understanding the migration of the ovarian border cells, embryonic blood cells, primordial germ cells, somatic gonadal precursors, and tracheal cells. Comparison of genes that regulate these processes to those that promote tumorigenesis and metastasis in mammals demonstrates that studies in fruit flies are uncovering new genes highly relevant to cancer biology.

Original languageEnglish (US)
Pages (from-to)86-91
Number of pages6
JournalCurrent Opinion in Genetics and Development
Volume14
Issue number1
DOIs
StatePublished - Feb 2004

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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