Genes expressed in human tumor endothelium

B. St. Croix, C. Rago, Victor E Velculescu, G. Traverso, K. E. Romans, Elizabeth A Montgomery, A. Lal, Gregory J Riggins, C. Lengauer, Bert Vogelstein, Kenneth W Kinzler

Research output: Contribution to journalArticle

Abstract

To gain a molecular understanding of tumor angiogenesis, we compared gene expression patterns of endothelial cells derived from blood vessels of normal and malignant colorectal tissues. Of over 170 transcripts predominantly expressed in the endothelium, 79 were differentially expressed, including 46 that were specifically elevated in tumor-associated endothelium. Several of these genes encode extracellular matrix proteins, but most are of unknown function. Most of these tumor endothelial markers were expressed in a wide range of tumor types, as well as in normal vessels associated with wound healing and corpus luteum formation. These studies demonstrate that tumor and normal endothelium are distinct at the molecular level, a finding that may have significant implications for the development of anti-angiogenic therapies.

Original languageEnglish (US)
Pages (from-to)1197-1202
Number of pages6
JournalScience
Volume289
Issue number5482
DOIs
StatePublished - Aug 18 2000

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Endothelium
Genes
Neoplasms
Extracellular Matrix Proteins
Corpus Luteum
Tumor Biomarkers
Wound Healing
Blood Vessels
Endothelial Cells
Gene Expression
Therapeutics

ASJC Scopus subject areas

  • General

Cite this

Genes expressed in human tumor endothelium. / St. Croix, B.; Rago, C.; Velculescu, Victor E; Traverso, G.; Romans, K. E.; Montgomery, Elizabeth A; Lal, A.; Riggins, Gregory J; Lengauer, C.; Vogelstein, Bert; Kinzler, Kenneth W.

In: Science, Vol. 289, No. 5482, 18.08.2000, p. 1197-1202.

Research output: Contribution to journalArticle

St. Croix, B, Rago, C, Velculescu, VE, Traverso, G, Romans, KE, Montgomery, EA, Lal, A, Riggins, GJ, Lengauer, C, Vogelstein, B & Kinzler, KW 2000, 'Genes expressed in human tumor endothelium', Science, vol. 289, no. 5482, pp. 1197-1202. https://doi.org/10.1126/science.289.5482.1197
St. Croix B, Rago C, Velculescu VE, Traverso G, Romans KE, Montgomery EA et al. Genes expressed in human tumor endothelium. Science. 2000 Aug 18;289(5482):1197-1202. https://doi.org/10.1126/science.289.5482.1197
St. Croix, B. ; Rago, C. ; Velculescu, Victor E ; Traverso, G. ; Romans, K. E. ; Montgomery, Elizabeth A ; Lal, A. ; Riggins, Gregory J ; Lengauer, C. ; Vogelstein, Bert ; Kinzler, Kenneth W. / Genes expressed in human tumor endothelium. In: Science. 2000 ; Vol. 289, No. 5482. pp. 1197-1202.
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