Genes and environment in neonatal intraventricular hemorrhage

Laura R. Ment, Ulrika Ådén, Charles R. Bauer, Henrietta S. Bada, Waldemar A. Carlo, Jeffrey R. Kaiser, Aiping Lin, Charles Michael Cotten, Jeffrey Murray, Grier Page, Mikko Hallman, Richard P. Lifton, Heping Zhang, Cindy Bryant, Christopher Cassady, Carmen Garcia, Yvette R. Johnson, Heidi E. Karpen, Martha M. Munden, Geneva ShoresJohn Cassese, Angelita M. Hensman, Elisa Vieira, Betty Vohr, Michael Wallach, James J. Cummings, Scott S. MacGilvray, Sherry Moseley, Vickie Trapanotto, Brenda Poindexter, Leslie Dawn Wilson, Shirley Wright-Coltart, Marco Bartocci, Gordana Printz, Andrew Hopper, Leon Smith, Beverly P. Wood, Lionel Young, Walter C. Allan, Jessica Alfsson, Karin Sävman, Stuart A. Royal, Daniel W. Young, Shirley Cosby, Crystal Helms, Teresita Angtuaco, N. Carol Sikes, Melanie J. Mason, R. Whit Hall, Harris L. Cohen, Gene targets for IVH study group, Neonatal research network genomics study group

Research output: Contribution to journalReview article

Abstract

Emerging data suggest intraventricular hemorrhage (IVH) of the preterm neonate is a complex disorder with contributions from both the environment and the genome. Environmental analyses suggest factors mediating both cerebral blood flow and angiogenesis contribute to IVH, while candidate gene studies report variants in angiogenesis, inflammation, and vascular pathways. Gene-by-environment interactions demonstrate the interaction between the environment and the genome, and a non-replicated genome-wide association study suggests that both environmental and genetic factors contribute to the risk for severe IVH in very low-birth weight preterm neonates.

Original languageEnglish (US)
Pages (from-to)592-603
Number of pages12
JournalSeminars in Perinatology
Volume39
Issue number8
DOIs
StatePublished - Dec 1 2015
Externally publishedYes

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Keywords

  • Genes
  • GWAS
  • Intraventricular hemorrhage
  • Neonate
  • Preterm

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Ment, L. R., Ådén, U., Bauer, C. R., Bada, H. S., Carlo, W. A., Kaiser, J. R., Lin, A., Cotten, C. M., Murray, J., Page, G., Hallman, M., Lifton, R. P., Zhang, H., Bryant, C., Cassady, C., Garcia, C., Johnson, Y. R., Karpen, H. E., Munden, M. M., ... Neonatal research network genomics study group (2015). Genes and environment in neonatal intraventricular hemorrhage. Seminars in Perinatology, 39(8), 592-603. https://doi.org/10.1053/j.semperi.2015.09.006