Genes and environment in neonatal intraventricular hemorrhage

Laura R. Ment, Ulrika Ådén, Charles R. Bauer, Henrietta S. Bada, Waldemar A. Carlo, Jeffrey R. Kaiser, Aiping Lin, Charles Michael Cotten, Jeffrey Murray, Grier Page, Mikko Hallman, Richard P. Lifton, Heping Zhang, Cindy Bryant, Christopher Cassady, Carmen Garcia, Yvette R. Johnson, Heidi E. Karpen, Martha M. Munden, Geneva ShoresJohn Cassese, Angelita M. Hensman, Elisa Vieira, Betty Vohr, Michael Wallach, James J. Cummings, Scott S. MacGilvray, Sherry Moseley, Vickie Trapanotto, Brenda Poindexter, Leslie Dawn Wilson, Shirley Wright-Coltart, Marco Bartocci, Gordana Printz, Andrew Hopper, Leon Smith, Beverly P. Wood, Lionel Young, Walter C. Allan, Jessica Alfsson, Karin Sävman, Stuart A. Royal, Daniel W. Young, Shirley Cosby, Crystal Helms, Teresita Angtuaco, N. Carol Sikes, Melanie J. Mason, R. Whit Hall, Harris L. Cohen, Gene targets for IVH study group, Neonatal research network genomics study group

Research output: Contribution to journalReview article

Abstract

Emerging data suggest intraventricular hemorrhage (IVH) of the preterm neonate is a complex disorder with contributions from both the environment and the genome. Environmental analyses suggest factors mediating both cerebral blood flow and angiogenesis contribute to IVH, while candidate gene studies report variants in angiogenesis, inflammation, and vascular pathways. Gene-by-environment interactions demonstrate the interaction between the environment and the genome, and a non-replicated genome-wide association study suggests that both environmental and genetic factors contribute to the risk for severe IVH in very low-birth weight preterm neonates.

Original languageEnglish (US)
Pages (from-to)592-603
Number of pages12
JournalSeminars in Perinatology
Volume39
Issue number8
DOIs
StatePublished - Dec 1 2015
Externally publishedYes

Fingerprint

Hemorrhage
Cerebrovascular Circulation
Newborn Infant
Genome
Genes
Gene-Environment Interaction
Very Low Birth Weight Infant
Genome-Wide Association Study
Statistical Factor Analysis
Blood Vessels
Inflammation

Keywords

  • Genes
  • GWAS
  • Intraventricular hemorrhage
  • Neonate
  • Preterm

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Ment, L. R., Ådén, U., Bauer, C. R., Bada, H. S., Carlo, W. A., Kaiser, J. R., ... Neonatal research network genomics study group (2015). Genes and environment in neonatal intraventricular hemorrhage. Seminars in Perinatology, 39(8), 592-603. https://doi.org/10.1053/j.semperi.2015.09.006

Genes and environment in neonatal intraventricular hemorrhage. / Ment, Laura R.; Ådén, Ulrika; Bauer, Charles R.; Bada, Henrietta S.; Carlo, Waldemar A.; Kaiser, Jeffrey R.; Lin, Aiping; Cotten, Charles Michael; Murray, Jeffrey; Page, Grier; Hallman, Mikko; Lifton, Richard P.; Zhang, Heping; Bryant, Cindy; Cassady, Christopher; Garcia, Carmen; Johnson, Yvette R.; Karpen, Heidi E.; Munden, Martha M.; Shores, Geneva; Cassese, John; Hensman, Angelita M.; Vieira, Elisa; Vohr, Betty; Wallach, Michael; Cummings, James J.; MacGilvray, Scott S.; Moseley, Sherry; Trapanotto, Vickie; Poindexter, Brenda; Wilson, Leslie Dawn; Wright-Coltart, Shirley; Bartocci, Marco; Printz, Gordana; Hopper, Andrew; Smith, Leon; Wood, Beverly P.; Young, Lionel; Allan, Walter C.; Alfsson, Jessica; Sävman, Karin; Royal, Stuart A.; Young, Daniel W.; Cosby, Shirley; Helms, Crystal; Angtuaco, Teresita; Carol Sikes, N.; Mason, Melanie J.; Whit Hall, R.; Cohen, Harris L.; Gene targets for IVH study group; Neonatal research network genomics study group.

In: Seminars in Perinatology, Vol. 39, No. 8, 01.12.2015, p. 592-603.

Research output: Contribution to journalReview article

Ment, LR, Ådén, U, Bauer, CR, Bada, HS, Carlo, WA, Kaiser, JR, Lin, A, Cotten, CM, Murray, J, Page, G, Hallman, M, Lifton, RP, Zhang, H, Bryant, C, Cassady, C, Garcia, C, Johnson, YR, Karpen, HE, Munden, MM, Shores, G, Cassese, J, Hensman, AM, Vieira, E, Vohr, B, Wallach, M, Cummings, JJ, MacGilvray, SS, Moseley, S, Trapanotto, V, Poindexter, B, Wilson, LD, Wright-Coltart, S, Bartocci, M, Printz, G, Hopper, A, Smith, L, Wood, BP, Young, L, Allan, WC, Alfsson, J, Sävman, K, Royal, SA, Young, DW, Cosby, S, Helms, C, Angtuaco, T, Carol Sikes, N, Mason, MJ, Whit Hall, R, Cohen, HL, Gene targets for IVH study group & Neonatal research network genomics study group 2015, 'Genes and environment in neonatal intraventricular hemorrhage', Seminars in Perinatology, vol. 39, no. 8, pp. 592-603. https://doi.org/10.1053/j.semperi.2015.09.006
Ment LR, Ådén U, Bauer CR, Bada HS, Carlo WA, Kaiser JR et al. Genes and environment in neonatal intraventricular hemorrhage. Seminars in Perinatology. 2015 Dec 1;39(8):592-603. https://doi.org/10.1053/j.semperi.2015.09.006
Ment, Laura R. ; Ådén, Ulrika ; Bauer, Charles R. ; Bada, Henrietta S. ; Carlo, Waldemar A. ; Kaiser, Jeffrey R. ; Lin, Aiping ; Cotten, Charles Michael ; Murray, Jeffrey ; Page, Grier ; Hallman, Mikko ; Lifton, Richard P. ; Zhang, Heping ; Bryant, Cindy ; Cassady, Christopher ; Garcia, Carmen ; Johnson, Yvette R. ; Karpen, Heidi E. ; Munden, Martha M. ; Shores, Geneva ; Cassese, John ; Hensman, Angelita M. ; Vieira, Elisa ; Vohr, Betty ; Wallach, Michael ; Cummings, James J. ; MacGilvray, Scott S. ; Moseley, Sherry ; Trapanotto, Vickie ; Poindexter, Brenda ; Wilson, Leslie Dawn ; Wright-Coltart, Shirley ; Bartocci, Marco ; Printz, Gordana ; Hopper, Andrew ; Smith, Leon ; Wood, Beverly P. ; Young, Lionel ; Allan, Walter C. ; Alfsson, Jessica ; Sävman, Karin ; Royal, Stuart A. ; Young, Daniel W. ; Cosby, Shirley ; Helms, Crystal ; Angtuaco, Teresita ; Carol Sikes, N. ; Mason, Melanie J. ; Whit Hall, R. ; Cohen, Harris L. ; Gene targets for IVH study group ; Neonatal research network genomics study group. / Genes and environment in neonatal intraventricular hemorrhage. In: Seminars in Perinatology. 2015 ; Vol. 39, No. 8. pp. 592-603.
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AU - Ment, Laura R.

AU - Ådén, Ulrika

AU - Bauer, Charles R.

AU - Bada, Henrietta S.

AU - Carlo, Waldemar A.

AU - Kaiser, Jeffrey R.

AU - Lin, Aiping

AU - Cotten, Charles Michael

AU - Murray, Jeffrey

AU - Page, Grier

AU - Hallman, Mikko

AU - Lifton, Richard P.

AU - Zhang, Heping

AU - Bryant, Cindy

AU - Cassady, Christopher

AU - Garcia, Carmen

AU - Johnson, Yvette R.

AU - Karpen, Heidi E.

AU - Munden, Martha M.

AU - Shores, Geneva

AU - Cassese, John

AU - Hensman, Angelita M.

AU - Vieira, Elisa

AU - Vohr, Betty

AU - Wallach, Michael

AU - Cummings, James J.

AU - MacGilvray, Scott S.

AU - Moseley, Sherry

AU - Trapanotto, Vickie

AU - Poindexter, Brenda

AU - Wilson, Leslie Dawn

AU - Wright-Coltart, Shirley

AU - Bartocci, Marco

AU - Printz, Gordana

AU - Hopper, Andrew

AU - Smith, Leon

AU - Wood, Beverly P.

AU - Young, Lionel

AU - Allan, Walter C.

AU - Alfsson, Jessica

AU - Sävman, Karin

AU - Royal, Stuart A.

AU - Young, Daniel W.

AU - Cosby, Shirley

AU - Helms, Crystal

AU - Angtuaco, Teresita

AU - Carol Sikes, N.

AU - Mason, Melanie J.

AU - Whit Hall, R.

AU - Cohen, Harris L.

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