@article{feae7ab14fb9474d8266eafbd0c4bec6,
title = "Genes and Environment in Multiple Sclerosis project: A platform to investigate multiple sclerosis risk",
abstract = "The Genes and Environment in Multiple Sclerosis project establishes a platform to investigate the events leading to multiple sclerosis (MS) in at-risk individuals. It has recruited 2,632 first-degree relatives from across the USA. Using an integrated genetic and environmental risk score, we identified subjects with twice the MS risk when compared to the average family member, and we report an initial incidence rate in these subjects that is 30 times greater than that of sporadic MS. We discuss the feasibility of large-scale studies of asymptomatic at-risk subjects that leverage modern tools of subject recruitment to execute collaborative projects.",
author = "Zongqi Xia and White, {Charles C.} and Owen, {Emily K.} and Korff, {Alina Von} and Clarkson, {Sarah R.} and McCabe, {Cristin A.} and Maria Cimpean and Winn, {Phoebe A.} and Ashley Hoesing and Steele, {Sonya U.} and Cortese, {Irene C.M.} and Tanuja Chitnis and Weiner, {Howard L.} and Reich, {Daniel S.} and Chibnik, {Lori B.} and {De Jager}, {Philip L.}",
note = "Funding Information: The GEMS study is supported by the National Multiple Sclerosis Society (RG-5003-A-2; P.L.D.J.), the NIH National Institute of Neurological Disorders and Stroke (K08-NS079493; Z.X.), and the Intramural Research Program of the National Institute of Neurological Disorders and Stroke (S.U.S., I.C.M.C., D.S.R.). Z.X. was a recipient of the Clinician Scientist Development Award from the National Multiple Sclerosis Society and the American Academy of Neurology (FAN 1755-A-1). P.L.D.J. was a Harry Weaver Neuroscience Scholar of the National Multiple Sclerosis Society (JF2138A1). We thank all of study participants for being part of the GEMS study; and Drs A. Ascherio and K. Munger for their invaluable advice on study design. Publisher Copyright: {\textcopyright} 2015 American Neurological Association.",
year = "2016",
month = feb,
day = "1",
doi = "10.1002/ana.24560",
language = "English (US)",
volume = "79",
pages = "178--189",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "2",
}