Genes and Atopic Phenotypes

Kathleen C. Barnes

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Significant advancements in the field of genetic epidemiology over the past several decades have greatly expanded our understanding of the pathogenesis of the atopic phenotypes. To date, multiple genome-wide linkage, candidate gene, and genome-wide association studies have elucidated genes (and in some cases, causal variants) associated with atopic dermatitis, allergic rhinitis, childhood asthma, and, to a lesser degree, food allergy, and these findings have been replicated in independent and often ethnically and racially diverse populations. Despite the complexities associated with coexisting phenotypes and environmental influences, genes common to all four atopic phenotypes, especially genes that are part of the adaptive and innate immune response and skin barrier dysfunction, may help to explain the molecular processes underlying the sequential appearance of the clinical manifestations characteristic of the atopic march.

Original languageEnglish (US)
Title of host publicationAllergy, Immunity and Tolerance in Early Childhood: The First Steps of the Atopic March
PublisherElsevier Inc.
Pages113-131
Number of pages19
ISBN (Print)9780127999302, 9780124202269
DOIs
StatePublished - Sep 30 2015
Externally publishedYes

Keywords

  • Allergic rhinitis
  • Asthma
  • Atopic dermatitis
  • Atopic march
  • Candidate gene
  • Food allergy
  • Genome-wide association studies (GWAS)
  • Linkage

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Barnes, K. C. (2015). Genes and Atopic Phenotypes. In Allergy, Immunity and Tolerance in Early Childhood: The First Steps of the Atopic March (pp. 113-131). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-420226-9.00008-5