Generation of suppressor T lymphocytes and monocytes by amphotericin B

S. J. Stewart, P. J. Spagnuolo, J. J. Ellner

Research output: Contribution to journalArticlepeer-review

Abstract

Amphotericin B, an anti-fungal polyene antibiotic, has profound immunomodulating properties in murine systems. Reports of similar effects in man are few. Amphotericin B 2.0 μg/ml reduced phytohemagglutinin-induced 3H-thymidine incorporation in peripheral blood mononuclear cells from control of 42,905 to 24,183 (experimental CPM minus control CPM) (p3 cells/well, AMB 87 ± 5 x 103 cells/well; p2 production during 18 hr of incubation from baseline 15.1 ± 2.8 ng/106 cells to 59.4 ± 17.8 ng/106 cells (p

Original languageEnglish (US)
Pages (from-to)135-139
Number of pages5
JournalJournal of Immunology
Volume127
Issue number1
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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