Generation of suppressor T lymphocytes and monocytes by amphotericin B

S. J. Stewart; P. J. Spagnuolo; J. J. Ellner

Generation of suppressor T lymphocytes and monocytes by amphotericin B

S. J. Stewart, P. J. Spagnuolo, J. J. Ellner

Research output: Contribution to journal › Article › peer-review

Abstract

Amphotericin B, an anti-fungal polyene antibiotic, has profound immunomodulating properties in murine systems. Reports of similar effects in man are few. Amphotericin B 2.0 μg/ml reduced phytohemagglutinin-induced ³H-thymidine incorporation in peripheral blood mononuclear cells from control of 42,905 to 24,183 (experimental CPM minus control CPM) (p3 cells/well, AMB 87 ± 5 x 10³ cells/well; p2 production during 18 hr of incubation from baseline 15.1 ± 2.8 ng/10⁶ cells to 59.4 ± 17.8 ng/10⁶ cells (p

Original language	English (US)
Pages (from-to)	135-139
Number of pages	5
Journal	Journal of Immunology
Volume	127
Issue number	1
State	Published - 1981
Externally published	Yes

ASJC Scopus subject areas

Immunology

Cite this

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title = "Generation of suppressor T lymphocytes and monocytes by amphotericin B",

abstract = "Amphotericin B, an anti-fungal polyene antibiotic, has profound immunomodulating properties in murine systems. Reports of similar effects in man are few. Amphotericin B 2.0 μg/ml reduced phytohemagglutinin-induced 3H-thymidine incorporation in peripheral blood mononuclear cells from control of 42,905 to 24,183 (experimental CPM minus control CPM) (p3 cells/well, AMB 87 ± 5 x 103 cells/well; p2 production during 18 hr of incubation from baseline 15.1 ± 2.8 ng/106 cells to 59.4 ± 17.8 ng/106 cells (p",

author = "Stewart, {S. J.} and Spagnuolo, {P. J.} and Ellner, {J. J.}",

year = "1981",

language = "English (US)",

volume = "127",

pages = "135--139",

journal = "Journal of Immunology",

issn = "0022-1767",

publisher = "American Association of Immunologists",

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T1 - Generation of suppressor T lymphocytes and monocytes by amphotericin B

AU - Stewart, S. J.

AU - Spagnuolo, P. J.

AU - Ellner, J. J.

PY - 1981

Y1 - 1981

N2 - Amphotericin B, an anti-fungal polyene antibiotic, has profound immunomodulating properties in murine systems. Reports of similar effects in man are few. Amphotericin B 2.0 μg/ml reduced phytohemagglutinin-induced 3H-thymidine incorporation in peripheral blood mononuclear cells from control of 42,905 to 24,183 (experimental CPM minus control CPM) (p3 cells/well, AMB 87 ± 5 x 103 cells/well; p2 production during 18 hr of incubation from baseline 15.1 ± 2.8 ng/106 cells to 59.4 ± 17.8 ng/106 cells (p

AB - Amphotericin B, an anti-fungal polyene antibiotic, has profound immunomodulating properties in murine systems. Reports of similar effects in man are few. Amphotericin B 2.0 μg/ml reduced phytohemagglutinin-induced 3H-thymidine incorporation in peripheral blood mononuclear cells from control of 42,905 to 24,183 (experimental CPM minus control CPM) (p3 cells/well, AMB 87 ± 5 x 103 cells/well; p2 production during 18 hr of incubation from baseline 15.1 ± 2.8 ng/106 cells to 59.4 ± 17.8 ng/106 cells (p

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Generation of suppressor T lymphocytes and monocytes by amphotericin B

Abstract

ASJC Scopus subject areas

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