Generation of Minute phenotypes by a transformed antisense ribosomal protein gene

Research output: Contribution to journalArticle


Antisense RNAs have been used for gene interference experiments in many cell types and organisms. However, relatively few experiments have been conducted with antisense genes integrated into the germ line. In Drosophila reduced ribosomal protein (r‐protein) gene function has been hypothesized to result in a Minute phenotype. In this report we examine the effects of antisense r‐protein 49 expression, a gene known to correspond to a Minute mutation An antisense rp49 gene driven by a strong and inducible promoter was transformed into the Drosophila germ line. Induction of this gene led to the development of flies with weak Minute phenotypes and to the transient arrest of oogenesis. Parameters that may affect the success of antisense gene inactivation are discussed. © 1992 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)256-263
Number of pages8
JournalDevelopmental Genetics
Issue number4
StatePublished - 1992
Externally publishedYes


  • Drosophila
  • Minute mutations
  • oogenesis

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology
  • Cell Biology

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