TY - JOUR
T1 - Generation of lytic and proliferative lymphoid clones to syngeneic tumor
T2 - In vitro and in vivo studies
AU - Rosenstein, Maury
AU - Rosenberg, Steven A.
N1 - Funding Information:
I Received August 23, 1983; accepted January 10, 1984. 2 Surgery Branch, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Public Health Service, U.S. Department of Health and Human Services, Bethesda, Md. 20205. .1 Address reprint requests to Dr. Rosenberg at Building 10, Room 2B42, National Institutes of Health, Bethesda, Md. 20205. 4 4-(2-Hydroxyethyl)-I-piperazine ethanesulfonic acid.
PY - 1984/5
Y1 - 1984/5
N2 - T-cell clones that exhibited both lytic and proliferative activity for the syngeneic FBL-3 lymphoma were isolated from in vitro sensitization cultures. These clones were Lyt-2+ and proliferated specifically to the FBL-3 lymphoma but not to other tumors of C57BL/6 origin, allogeneic tumor, or C57BL/6 normal lymphocytes. Adoptive transfer of clones exhibiting both proliferative and cytotoxic activity prolonged survival and occasionally cured the animals of disseminated FBL-3 lymphomas, while T-cell clones exhibiting lytic but no proliferative activity.
AB - T-cell clones that exhibited both lytic and proliferative activity for the syngeneic FBL-3 lymphoma were isolated from in vitro sensitization cultures. These clones were Lyt-2+ and proliferated specifically to the FBL-3 lymphoma but not to other tumors of C57BL/6 origin, allogeneic tumor, or C57BL/6 normal lymphocytes. Adoptive transfer of clones exhibiting both proliferative and cytotoxic activity prolonged survival and occasionally cured the animals of disseminated FBL-3 lymphomas, while T-cell clones exhibiting lytic but no proliferative activity.
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U2 - 10.1093/jnci/72.5.1161
DO - 10.1093/jnci/72.5.1161
M3 - Article
C2 - 6609266
AN - SCOPUS:0021271495
SN - 0027-8874
VL - 72
SP - 1161
EP - 1165
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 5
ER -