Generation of lytic and proliferative lymphoid clones to syngeneic tumor: In vitro and in vivo studies

Maury Rosenstein, Steven A. Rosenberg

Research output: Contribution to journalArticlepeer-review

Abstract

T-cell clones that exhibited both lytic and proliferative activity for the syngeneic FBL-3 lymphoma were isolated from in vitro sensitization cultures. These clones were Lyt-2+ and proliferated specifically to the FBL-3 lymphoma but not to other tumors of C57BL/6 origin, allogeneic tumor, or C57BL/6 normal lymphocytes. Adoptive transfer of clones exhibiting both proliferative and cytotoxic activity prolonged survival and occasionally cured the animals of disseminated FBL-3 lymphomas, while T-cell clones exhibiting lytic but no proliferative activity.

Original languageEnglish (US)
Pages (from-to)1161-1165
Number of pages5
JournalJournal of the National Cancer Institute
Volume72
Issue number5
DOIs
StatePublished - May 1984

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint

Dive into the research topics of 'Generation of lytic and proliferative lymphoid clones to syngeneic tumor: In vitro and in vivo studies'. Together they form a unique fingerprint.

Cite this