Generation of an Anti—Interleukin 2 Factor in Healing Wounds

Robert J. Breslin, Adrian Barbul, Thomas S. Kupper, John P. Knud Hansen, Hannah L. Wasserkrug, Gershon Efron

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Previously we have noted that fluid obtained from ten-day-old healing wounds noncytotoxically inhibits the blastogenesis of lymphocytes in response to mitogens or antigens. Since these lymphocytic responses are interleukin 2 (IL-2)—mediated, we looked for a specific IL-2 inhibitor in wound fluid. We have found that wound fluid blocks the response of thymic lymphocytes and of two cloned T-helper cell lines (D10 and HT2) to exogenous human recombinant IL-2. The wound fluid enhances fibroblast proliferation, thus demonstrating that its proliferative inhibitory activity is specific for lymphocytes. The findings suggest that wound fluid contains a factor that impairs lymphocyte response to IL-2, probably at the receptor or postreceptor level.

Original languageEnglish (US)
Pages (from-to)305-308
Number of pages4
JournalArchives of surgery
Issue number3
StatePublished - Mar 1988

ASJC Scopus subject areas

  • Surgery


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