Generation of an Anti—Interleukin 2 Factor in Healing Wounds

Robert J. Breslin, Adrian Barbul, Thomas S. Kupper, John P. Knud Hansen, Hannah L. Wasserkrug, Gershon Efron

Research output: Contribution to journalArticle

Abstract

Previously we have noted that fluid obtained from ten-day-old healing wounds noncytotoxically inhibits the blastogenesis of lymphocytes in response to mitogens or antigens. Since these lymphocytic responses are interleukin 2 (IL-2)—mediated, we looked for a specific IL-2 inhibitor in wound fluid. We have found that wound fluid blocks the response of thymic lymphocytes and of two cloned T-helper cell lines (D10 and HT2) to exogenous human recombinant IL-2. The wound fluid enhances fibroblast proliferation, thus demonstrating that its proliferative inhibitory activity is specific for lymphocytes. The findings suggest that wound fluid contains a factor that impairs lymphocyte response to IL-2, probably at the receptor or postreceptor level.

Original languageEnglish (US)
Pages (from-to)305-308
Number of pages4
JournalArchives of surgery
Volume123
Issue number3
DOIs
StatePublished - Mar 1988

ASJC Scopus subject areas

  • Surgery

Fingerprint Dive into the research topics of 'Generation of an Anti—Interleukin 2 Factor in Healing Wounds'. Together they form a unique fingerprint.

  • Cite this

    Breslin, R. J., Barbul, A., Kupper, T. S., Knud Hansen, J. P., Wasserkrug, H. L., & Efron, G. (1988). Generation of an Anti—Interleukin 2 Factor in Healing Wounds. Archives of surgery, 123(3), 305-308. https://doi.org/10.1001/archsurg.1988.01400270039005