Generation of a Core Set of Items to Develop Classification Criteria for Scleroderma Renal Crisis Using Consensus Methodology

the Scleroderma Clinical Trials Consortium Scleroderma Renal Crisis Working Group

Research output: Contribution to journalArticle

Abstract

Objective: To generate a core set of items to develop classification criteria for scleroderma renal crisis (SRC) using consensus methodology. Methods: An international, multidisciplinary panel of experts was invited to participate in a 3-round Delphi exercise developed using a survey based on items identified by a scoping review. In round 1, participants were asked to identify omissions and clarify ambiguities regarding the items in the survey. In round 2, participants were asked to rate the validity and feasibility of the items using Likert-type scales ranging from 1 to 9 (where 1 = very invalid/unfeasible, 5 = uncertain, and 9 = very valid/feasible). In round 3, participants reviewed the results and comments from round 2 and were asked to provide final ratings. Items rated as highly valid and feasible (median scores ≥7 for each) in round 3 were selected as the provisional core set of items. A consensus meeting using a nominal group technique was conducted to further reduce the core set of items. Results: Ninety-nine experts from 16 countries participated in the Delphi exercise. Of the 31 items in the survey, consensus was achieved on 13, in the categories hypertension, renal insufficiency, proteinuria, and hemolysis. Eleven experts took part in the nominal group technique discussion, where consensus was achieved in 5 domains: blood pressure, acute kidney injury, microangiopathic hemolytic anemia, target organ dysfunction, and renal histopathology. Conclusion: A core set of items that characterize SRC was identified using consensus methodology. This core set will be used in future data-driven phases of this project to develop classification criteria for SRC.

Original languageEnglish (US)
Pages (from-to)964-971
Number of pages8
JournalArthritis and Rheumatology
Volume71
Issue number6
DOIs
StatePublished - Jun 1 2019

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Kidney
Hemolytic Anemia
Hemolysis
Proteinuria
Acute Kidney Injury
Renal Insufficiency
Blood Pressure
Hypertension
Surveys and Questionnaires

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology

Cite this

Generation of a Core Set of Items to Develop Classification Criteria for Scleroderma Renal Crisis Using Consensus Methodology. / the Scleroderma Clinical Trials Consortium Scleroderma Renal Crisis Working Group.

In: Arthritis and Rheumatology, Vol. 71, No. 6, 01.06.2019, p. 964-971.

Research output: Contribution to journalArticle

the Scleroderma Clinical Trials Consortium Scleroderma Renal Crisis Working Group 2019, 'Generation of a Core Set of Items to Develop Classification Criteria for Scleroderma Renal Crisis Using Consensus Methodology', Arthritis and Rheumatology, vol. 71, no. 6, pp. 964-971. https://doi.org/10.1002/art.40809
the Scleroderma Clinical Trials Consortium Scleroderma Renal Crisis Working Group. / Generation of a Core Set of Items to Develop Classification Criteria for Scleroderma Renal Crisis Using Consensus Methodology. In: Arthritis and Rheumatology. 2019 ; Vol. 71, No. 6. pp. 964-971.
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abstract = "Objective: To generate a core set of items to develop classification criteria for scleroderma renal crisis (SRC) using consensus methodology. Methods: An international, multidisciplinary panel of experts was invited to participate in a 3-round Delphi exercise developed using a survey based on items identified by a scoping review. In round 1, participants were asked to identify omissions and clarify ambiguities regarding the items in the survey. In round 2, participants were asked to rate the validity and feasibility of the items using Likert-type scales ranging from 1 to 9 (where 1 = very invalid/unfeasible, 5 = uncertain, and 9 = very valid/feasible). In round 3, participants reviewed the results and comments from round 2 and were asked to provide final ratings. Items rated as highly valid and feasible (median scores ≥7 for each) in round 3 were selected as the provisional core set of items. A consensus meeting using a nominal group technique was conducted to further reduce the core set of items. Results: Ninety-nine experts from 16 countries participated in the Delphi exercise. Of the 31 items in the survey, consensus was achieved on 13, in the categories hypertension, renal insufficiency, proteinuria, and hemolysis. Eleven experts took part in the nominal group technique discussion, where consensus was achieved in 5 domains: blood pressure, acute kidney injury, microangiopathic hemolytic anemia, target organ dysfunction, and renal histopathology. Conclusion: A core set of items that characterize SRC was identified using consensus methodology. This core set will be used in future data-driven phases of this project to develop classification criteria for SRC.",
author = "{the Scleroderma Clinical Trials Consortium Scleroderma Renal Crisis Working Group} and Butler, {Emily Ann} and Murray Baron and Fogo, {Agnes B.} and Tracy Frech and Cybele Ghossein and Eric Hachulla and Sabrina Hoa and Johnson, {Sindhu R.} and Dinesh Khanna and Luc Mouthon and Mandana Nikpour and Susanna Proudman and Virginia Steen and Edward Stern and John Varga and Christopher Denton and Marie Hudson and April Barnado and Bernstein, {Elana J.} and Francesco Boin and Yolanda Braun-Moscovici and Castelino, {Flavia V.} and Catoggio, {Luis J.} and Marco Matucci-Cerinic and Lorinda Chung and Philip Clements and Csuka, {Mary Ellen} and {De Langhe}, Ellen and J{\"o}rg Distler and Oliver Distler and Farge, {Dominique Claire} and Aryeh Fischer and Armando Gabrielli and Minoru Hasegawa and Samina Hayat and Ariane Herrick and Roger Hesselstrand and Vivien Hsu and Michael Hughes and Nicolas Hunzelmann and Laura Hummers and Florenzo Iannone and Francesca Ingegnoli and Soren Jacobsen and Yasushi Kawaguchi and Martial Koenig and Masataka Kuwana and Jan Lenaerts and Zsuzsanna McMahan and Ami Shah",
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AU - the Scleroderma Clinical Trials Consortium Scleroderma Renal Crisis Working Group

AU - Butler, Emily Ann

AU - Baron, Murray

AU - Fogo, Agnes B.

AU - Frech, Tracy

AU - Ghossein, Cybele

AU - Hachulla, Eric

AU - Hoa, Sabrina

AU - Johnson, Sindhu R.

AU - Khanna, Dinesh

AU - Mouthon, Luc

AU - Nikpour, Mandana

AU - Proudman, Susanna

AU - Steen, Virginia

AU - Stern, Edward

AU - Varga, John

AU - Denton, Christopher

AU - Hudson, Marie

AU - Barnado, April

AU - Bernstein, Elana J.

AU - Boin, Francesco

AU - Braun-Moscovici, Yolanda

AU - Castelino, Flavia V.

AU - Catoggio, Luis J.

AU - Matucci-Cerinic, Marco

AU - Chung, Lorinda

AU - Clements, Philip

AU - Csuka, Mary Ellen

AU - De Langhe, Ellen

AU - Distler, Jörg

AU - Distler, Oliver

AU - Farge, Dominique Claire

AU - Fischer, Aryeh

AU - Gabrielli, Armando

AU - Hasegawa, Minoru

AU - Hayat, Samina

AU - Herrick, Ariane

AU - Hesselstrand, Roger

AU - Hsu, Vivien

AU - Hughes, Michael

AU - Hunzelmann, Nicolas

AU - Hummers, Laura

AU - Iannone, Florenzo

AU - Ingegnoli, Francesca

AU - Jacobsen, Soren

AU - Kawaguchi, Yasushi

AU - Koenig, Martial

AU - Kuwana, Masataka

AU - Lenaerts, Jan

AU - McMahan, Zsuzsanna

AU - Shah, Ami

PY - 2019/6/1

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N2 - Objective: To generate a core set of items to develop classification criteria for scleroderma renal crisis (SRC) using consensus methodology. Methods: An international, multidisciplinary panel of experts was invited to participate in a 3-round Delphi exercise developed using a survey based on items identified by a scoping review. In round 1, participants were asked to identify omissions and clarify ambiguities regarding the items in the survey. In round 2, participants were asked to rate the validity and feasibility of the items using Likert-type scales ranging from 1 to 9 (where 1 = very invalid/unfeasible, 5 = uncertain, and 9 = very valid/feasible). In round 3, participants reviewed the results and comments from round 2 and were asked to provide final ratings. Items rated as highly valid and feasible (median scores ≥7 for each) in round 3 were selected as the provisional core set of items. A consensus meeting using a nominal group technique was conducted to further reduce the core set of items. Results: Ninety-nine experts from 16 countries participated in the Delphi exercise. Of the 31 items in the survey, consensus was achieved on 13, in the categories hypertension, renal insufficiency, proteinuria, and hemolysis. Eleven experts took part in the nominal group technique discussion, where consensus was achieved in 5 domains: blood pressure, acute kidney injury, microangiopathic hemolytic anemia, target organ dysfunction, and renal histopathology. Conclusion: A core set of items that characterize SRC was identified using consensus methodology. This core set will be used in future data-driven phases of this project to develop classification criteria for SRC.

AB - Objective: To generate a core set of items to develop classification criteria for scleroderma renal crisis (SRC) using consensus methodology. Methods: An international, multidisciplinary panel of experts was invited to participate in a 3-round Delphi exercise developed using a survey based on items identified by a scoping review. In round 1, participants were asked to identify omissions and clarify ambiguities regarding the items in the survey. In round 2, participants were asked to rate the validity and feasibility of the items using Likert-type scales ranging from 1 to 9 (where 1 = very invalid/unfeasible, 5 = uncertain, and 9 = very valid/feasible). In round 3, participants reviewed the results and comments from round 2 and were asked to provide final ratings. Items rated as highly valid and feasible (median scores ≥7 for each) in round 3 were selected as the provisional core set of items. A consensus meeting using a nominal group technique was conducted to further reduce the core set of items. Results: Ninety-nine experts from 16 countries participated in the Delphi exercise. Of the 31 items in the survey, consensus was achieved on 13, in the categories hypertension, renal insufficiency, proteinuria, and hemolysis. Eleven experts took part in the nominal group technique discussion, where consensus was achieved in 5 domains: blood pressure, acute kidney injury, microangiopathic hemolytic anemia, target organ dysfunction, and renal histopathology. Conclusion: A core set of items that characterize SRC was identified using consensus methodology. This core set will be used in future data-driven phases of this project to develop classification criteria for SRC.

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