Generation and propagation of ectopic beats induced by spatially localized Na-K pump inhibition in atrial network models

R. L. Winslow, A. Varghese, D. Noble, G. Adlakha, A. Hoythya

Research output: Contribution to journalArticlepeer-review

Abstract

A biophysically detailed two-dimensional network model of the cardiac atrium has been implemented on the Thinking Machines massively parallel CM-5 supercomputer. The model is used to study the effects of spatially localized inhibition of the Na-K pump. Na overloading produced by pump inhibition can induce spontaneous, propagating ectopic beats within the network. At a cell-to-cell coupling value yielding a realistic plane wave conduction velocity of 0.6 m s-1, pump inhibition in roughly 1000 cells can induce propagating ectopic beats in a 512 x 512 lattice of cells.

Original languageEnglish (US)
Pages (from-to)55-61
Number of pages7
JournalProceedings of the Royal Society B: Biological Sciences
Volume253
Issue number1339
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

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