Abstract
A biophysically detailed two-dimensional network model of the cardiac atrium has been implemented on the Thinking Machines massively parallel CM-5 supercomputer. The model is used to study the effects of spatially localized inhibition of the Na-K pump. Na overloading produced by pump inhibition can induce spontaneous, propagating ectopic beats within the network. At a cell-to-cell coupling value yielding a realistic plane wave conduction velocity of 0.6 m s-1, pump inhibition in roughly 1000 cells can induce propagating ectopic beats in a 512 x 512 lattice of cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 55-61 |
| Number of pages | 7 |
| Journal | Proceedings of the Royal Society B: Biological Sciences |
| Volume | 253 |
| Issue number | 1339 |
| State | Published - 1993 |
ASJC Scopus subject areas
- General Immunology and Microbiology
- General Environmental Science
- General Biochemistry, Genetics and Molecular Biology
- General Agricultural and Biological Sciences