TY - JOUR
T1 - Generation and characterization of a novel human iPSC line from a resilient Alzheimer's disease patient
AU - Das, Debamitra
AU - Li, Jiaxin
AU - Liu, Senquan
AU - Oh, Esther
AU - Cheng, Linzhao
AU - Lyketsos, Constantine
AU - Mahairaki, Vasiliki
N1 - Publisher Copyright:
© 2020 The Authors
PY - 2020/10
Y1 - 2020/10
N2 - Alzheimer's disease (AD) is a progressive neurodegenerative disease that is the major cause of dementia in older people. Here, we report the derivation of human induced pluripotent stem cells (iPSCs) from an AD patient at age of 80 who has the APOE ε4/ε4 genotype and is resilient to cognitive decline for 10 years. The iPSCs reprogrammed from the blood cells of this patient by transient expression of pluripotency genes maintain the ε4/ε4 genotype, are karyotypically normal and display typical iPSC characteristics. Upon differentiation, the iPSCs are able to differentiate into cells of the three germ layers, confirming their pluripotency.
AB - Alzheimer's disease (AD) is a progressive neurodegenerative disease that is the major cause of dementia in older people. Here, we report the derivation of human induced pluripotent stem cells (iPSCs) from an AD patient at age of 80 who has the APOE ε4/ε4 genotype and is resilient to cognitive decline for 10 years. The iPSCs reprogrammed from the blood cells of this patient by transient expression of pluripotency genes maintain the ε4/ε4 genotype, are karyotypically normal and display typical iPSC characteristics. Upon differentiation, the iPSCs are able to differentiate into cells of the three germ layers, confirming their pluripotency.
UR - http://www.scopus.com/inward/record.url?scp=85090341120&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85090341120&partnerID=8YFLogxK
U2 - 10.1016/j.scr.2020.101979
DO - 10.1016/j.scr.2020.101979
M3 - Article
C2 - 32916633
AN - SCOPUS:85090341120
SN - 1873-5061
VL - 48
JO - Stem Cell Research
JF - Stem Cell Research
M1 - 101979
ER -