Generating an Artificial Intestine for the Treatment of Short Bowel Syndrome

Mark L. Kovler, David J. Hackam

Research output: Contribution to journalReview articlepeer-review

Abstract

Intestinal failure is defined as the inability to maintain fluid, nutrition, energy, and micronutrient balance that leads to the inability to gain or maintain weight, resulting in malnutrition and dehydration. Causes of intestinal failure include short bowel syndrome (ie, the physical loss of intestinal surface area and severe intestinal dysmotility). For patients with intestinal failure who fail to achieve enteral autonomy through intestinal rehabilitation programs, the current treatment options are expensive and associated with severe complications. Therefore, the need persists for next-generation therapies, including cell-based therapy, to increase intestinal regeneration, and development of the tissue-engineered small intestine.

Original languageEnglish (US)
Pages (from-to)585-605
Number of pages21
JournalGastroenterology Clinics of North America
Volume48
Issue number4
DOIs
StatePublished - Dec 2019

Keywords

  • Artificial intestine
  • Intestinal stem cells
  • Tissue engineering

ASJC Scopus subject areas

  • Gastroenterology

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