Generalized immune activation in pulmonary tuberculosis: Co-activation with HIV infection

G. Vanham, K. Edmonds, L. Qing, D. Hom, Z. Toossi, B. Jones, C. L. Daley, R. Huebner, L. Kestens, P. Gigase, J. J. Ellner

Research output: Contribution to journalArticle

Abstract

Parameters of immune activation/differentiation were studied in a group of newly diagnosed HIV- and HIV+ pulmonary tuberculosis (TB) patients. Compared with controls, HLA-DR expression on both CD4 and CD8 T cells from the HIV- TB patients was approximately doubled; HLA-DR on T cells from the HIV+ group was tripled. The monocytes from both groups of patients expressed abnormally high levels of the Fcγ receptors I and III. Serum levels of tumour necrosis factor-alpha (TNF-α), neopterin and β2-microglobulin were increased in HIV- and even more so in HIV+ TB patients. The expression of HLA-DR on T cell subsets and of FcγR on monocytes correlated with each other, but not with serum activation markers. This pattern of non-specific activation during TB infection may be associated with enhanced susceptibility to HIV infection.

Original languageEnglish (US)
Pages (from-to)30-34
Number of pages5
JournalClinical and Experimental Immunology
Volume103
Issue number1
StatePublished - 1996
Externally publishedYes

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Keywords

  • FCγ receptor
  • HIV
  • HLA-DR
  • Immune activation
  • Tuberculosis

ASJC Scopus subject areas

  • Immunology

Cite this

Vanham, G., Edmonds, K., Qing, L., Hom, D., Toossi, Z., Jones, B., Daley, C. L., Huebner, R., Kestens, L., Gigase, P., & Ellner, J. J. (1996). Generalized immune activation in pulmonary tuberculosis: Co-activation with HIV infection. Clinical and Experimental Immunology, 103(1), 30-34.