Generalized anxiety modulates frontal and limbic activation in major depression

Michael W. Schlund, Guillermo Verduzco, Michael F. Cataldo, Rudolf Hoehn-Saric

Research output: Research - peer-reviewArticle

Abstract

Background: Anxiety is relatively common in depression and capable of modifying the severity and course of depression. Yet our understanding of how anxiety modulates frontal and limbic activation in depression is limited.Methods: We used functional magnetic resonance imaging and two emotional information processing tasks to examine frontal and limbic activation in ten patients with major depression and comorbid with preceding generalized anxiety (MDD/GAD) and ten non-depressed controls.Results: Consistent with prior studies on depression, MDD/GAD patients showed hypoactivation in medial and middle frontal regions, as well as in the anterior cingulate, cingulate and insula. However, heightened anxiety in MDD/GAD patients was associated with increased activation in middle frontal regions and the insula and the effects varied with the type of emotional information presented.Conclusions: Our findings highlight frontal and limbic hypoactivation in patients with depression and comorbid anxiety and indicate that anxiety level may modulate frontal and limbic activation depending upon the emotional context. One implication of this finding is that divergent findings reported in the imaging literature on depression could reflect modulation of activation by anxiety level in response to different types of emotional information.

LanguageEnglish (US)
Article number8
JournalBehavioral and Brain Functions
Volume8
DOIs
StatePublished - Feb 9 2012

Fingerprint

Anxiety
Depression
Gyrus Cinguli
Automatic Data Processing
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Biological Psychiatry
  • Cognitive Neuroscience
  • Medicine(all)

Cite this

Generalized anxiety modulates frontal and limbic activation in major depression. / Schlund, Michael W.; Verduzco, Guillermo; Cataldo, Michael F.; Hoehn-Saric, Rudolf.

In: Behavioral and Brain Functions, Vol. 8, 8, 09.02.2012.

Research output: Research - peer-reviewArticle

@article{3150dfd0acfe4f5ba971e155cbe11625,
title = "Generalized anxiety modulates frontal and limbic activation in major depression",
abstract = "Background: Anxiety is relatively common in depression and capable of modifying the severity and course of depression. Yet our understanding of how anxiety modulates frontal and limbic activation in depression is limited.Methods: We used functional magnetic resonance imaging and two emotional information processing tasks to examine frontal and limbic activation in ten patients with major depression and comorbid with preceding generalized anxiety (MDD/GAD) and ten non-depressed controls.Results: Consistent with prior studies on depression, MDD/GAD patients showed hypoactivation in medial and middle frontal regions, as well as in the anterior cingulate, cingulate and insula. However, heightened anxiety in MDD/GAD patients was associated with increased activation in middle frontal regions and the insula and the effects varied with the type of emotional information presented.Conclusions: Our findings highlight frontal and limbic hypoactivation in patients with depression and comorbid anxiety and indicate that anxiety level may modulate frontal and limbic activation depending upon the emotional context. One implication of this finding is that divergent findings reported in the imaging literature on depression could reflect modulation of activation by anxiety level in response to different types of emotional information.",
author = "Schlund, {Michael W.} and Guillermo Verduzco and Cataldo, {Michael F.} and Rudolf Hoehn-Saric",
year = "2012",
month = "2",
doi = "10.1186/1744-9081-8-8",
volume = "8",
journal = "Behavioral and Brain Functions",
issn = "1744-9081",
publisher = "BioMed Central",

}

TY - JOUR

T1 - Generalized anxiety modulates frontal and limbic activation in major depression

AU - Schlund,Michael W.

AU - Verduzco,Guillermo

AU - Cataldo,Michael F.

AU - Hoehn-Saric,Rudolf

PY - 2012/2/9

Y1 - 2012/2/9

N2 - Background: Anxiety is relatively common in depression and capable of modifying the severity and course of depression. Yet our understanding of how anxiety modulates frontal and limbic activation in depression is limited.Methods: We used functional magnetic resonance imaging and two emotional information processing tasks to examine frontal and limbic activation in ten patients with major depression and comorbid with preceding generalized anxiety (MDD/GAD) and ten non-depressed controls.Results: Consistent with prior studies on depression, MDD/GAD patients showed hypoactivation in medial and middle frontal regions, as well as in the anterior cingulate, cingulate and insula. However, heightened anxiety in MDD/GAD patients was associated with increased activation in middle frontal regions and the insula and the effects varied with the type of emotional information presented.Conclusions: Our findings highlight frontal and limbic hypoactivation in patients with depression and comorbid anxiety and indicate that anxiety level may modulate frontal and limbic activation depending upon the emotional context. One implication of this finding is that divergent findings reported in the imaging literature on depression could reflect modulation of activation by anxiety level in response to different types of emotional information.

AB - Background: Anxiety is relatively common in depression and capable of modifying the severity and course of depression. Yet our understanding of how anxiety modulates frontal and limbic activation in depression is limited.Methods: We used functional magnetic resonance imaging and two emotional information processing tasks to examine frontal and limbic activation in ten patients with major depression and comorbid with preceding generalized anxiety (MDD/GAD) and ten non-depressed controls.Results: Consistent with prior studies on depression, MDD/GAD patients showed hypoactivation in medial and middle frontal regions, as well as in the anterior cingulate, cingulate and insula. However, heightened anxiety in MDD/GAD patients was associated with increased activation in middle frontal regions and the insula and the effects varied with the type of emotional information presented.Conclusions: Our findings highlight frontal and limbic hypoactivation in patients with depression and comorbid anxiety and indicate that anxiety level may modulate frontal and limbic activation depending upon the emotional context. One implication of this finding is that divergent findings reported in the imaging literature on depression could reflect modulation of activation by anxiety level in response to different types of emotional information.

UR - http://www.scopus.com/inward/record.url?scp=84856780600&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856780600&partnerID=8YFLogxK

U2 - 10.1186/1744-9081-8-8

DO - 10.1186/1744-9081-8-8

M3 - Article

VL - 8

JO - Behavioral and Brain Functions

T2 - Behavioral and Brain Functions

JF - Behavioral and Brain Functions

SN - 1744-9081

M1 - 8

ER -