Generalizability of neuroimaging studies in 5 common psychiatric disorders based on the national epidemiologic survey on alcohol and related conditions (NESARC)

Carlos Blanco, Melanie M. Wall, Martin Lindquist, Jorge Mario Rodruez-Ferndez, Silvia Franco, Shuai Wang, Mark Olfson

Research output: Contribution to journalArticle

Abstract

Objective: Although neuroimaging studies have an important role in psychiatric nosology and treatment development, little is known about the representativeness of participants in neuroimaging research. We estimated the effects of commonly used study eligibility criteria on the representativeness of neuroimaging research participants in relation to the general population with the psychiatric disorders of interest. Methods: Common eligibility criteria were applied from 112 published neuroimaging studies of DSM-IV nicotine dependence (13 studies), alcohol dependence (12 studies), drug use disorders (13 studies), major depressive disorder (MDD) (37 studies), and posttraumatic stress disorder (PTSD) (36 studies) to representative US samples with these conditions from the 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) (n = 43,093). The analyses were repeated with NESARC respondents with the disorders and substantial psychosocial impairment. Results: Most NESARC respondents with nicotine dependence (64.1%), alcohol dependence (57.7%), drug use disorders (86.6%), and PTSD (66.9%), though not with MDD (18.2%), would have been excluded by eligibility criteria used in at least half of the relevant neuroimaging studies. Across the diagnostic groups, comorbid psychiatric and general medical conditions resulted in the largest percentages of exclusions. Corresponding analyses limited to respondents with substantial impairment excluded larger percentages with nicotine dependence (77.6%), alcohol dependence (75.8%), drug use disorders (93.5%), and PTSD (76.8%), though not MDD (18.3%). Conclusions: Neuroimaging studies tend to recruit highly selected samples with the psychiatric disorders of interest that markedly underrepresent individuals with common comorbid conditions. Larger studies with less restrictive eligibility criteria may promote translation of advances in neuroimaging research to populations commonly encountered in clinical practice.

Original languageEnglish (US)
Pages (from-to)e1618-e1625
JournalJournal of Clinical Psychiatry
Volume77
Issue number12
DOIs
StatePublished - Dec 1 2016

Fingerprint

Neuroimaging
Psychiatry
Alcohols
Tobacco Use Disorder
Major Depressive Disorder
Post-Traumatic Stress Disorders
Alcoholism
Substance-Related Disorders
Research
Surveys and Questionnaires
Diagnostic and Statistical Manual of Mental Disorders
Population

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Generalizability of neuroimaging studies in 5 common psychiatric disorders based on the national epidemiologic survey on alcohol and related conditions (NESARC). / Blanco, Carlos; Wall, Melanie M.; Lindquist, Martin; Rodruez-Ferndez, Jorge Mario; Franco, Silvia; Wang, Shuai; Olfson, Mark.

In: Journal of Clinical Psychiatry, Vol. 77, No. 12, 01.12.2016, p. e1618-e1625.

Research output: Contribution to journalArticle

Blanco, Carlos ; Wall, Melanie M. ; Lindquist, Martin ; Rodruez-Ferndez, Jorge Mario ; Franco, Silvia ; Wang, Shuai ; Olfson, Mark. / Generalizability of neuroimaging studies in 5 common psychiatric disorders based on the national epidemiologic survey on alcohol and related conditions (NESARC). In: Journal of Clinical Psychiatry. 2016 ; Vol. 77, No. 12. pp. e1618-e1625.
@article{7801ff0245b24a679f0f02ee16e8b860,
title = "Generalizability of neuroimaging studies in 5 common psychiatric disorders based on the national epidemiologic survey on alcohol and related conditions (NESARC)",
abstract = "Objective: Although neuroimaging studies have an important role in psychiatric nosology and treatment development, little is known about the representativeness of participants in neuroimaging research. We estimated the effects of commonly used study eligibility criteria on the representativeness of neuroimaging research participants in relation to the general population with the psychiatric disorders of interest. Methods: Common eligibility criteria were applied from 112 published neuroimaging studies of DSM-IV nicotine dependence (13 studies), alcohol dependence (12 studies), drug use disorders (13 studies), major depressive disorder (MDD) (37 studies), and posttraumatic stress disorder (PTSD) (36 studies) to representative US samples with these conditions from the 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) (n = 43,093). The analyses were repeated with NESARC respondents with the disorders and substantial psychosocial impairment. Results: Most NESARC respondents with nicotine dependence (64.1{\%}), alcohol dependence (57.7{\%}), drug use disorders (86.6{\%}), and PTSD (66.9{\%}), though not with MDD (18.2{\%}), would have been excluded by eligibility criteria used in at least half of the relevant neuroimaging studies. Across the diagnostic groups, comorbid psychiatric and general medical conditions resulted in the largest percentages of exclusions. Corresponding analyses limited to respondents with substantial impairment excluded larger percentages with nicotine dependence (77.6{\%}), alcohol dependence (75.8{\%}), drug use disorders (93.5{\%}), and PTSD (76.8{\%}), though not MDD (18.3{\%}). Conclusions: Neuroimaging studies tend to recruit highly selected samples with the psychiatric disorders of interest that markedly underrepresent individuals with common comorbid conditions. Larger studies with less restrictive eligibility criteria may promote translation of advances in neuroimaging research to populations commonly encountered in clinical practice.",
author = "Carlos Blanco and Wall, {Melanie M.} and Martin Lindquist and Rodruez-Ferndez, {Jorge Mario} and Silvia Franco and Shuai Wang and Mark Olfson",
year = "2016",
month = "12",
day = "1",
doi = "10.4088/JCP.15m10264",
language = "English (US)",
volume = "77",
pages = "e1618--e1625",
journal = "Journal of Clinical Psychiatry",
issn = "0160-6689",
publisher = "Physicians Postgraduate Press Inc.",
number = "12",

}

TY - JOUR

T1 - Generalizability of neuroimaging studies in 5 common psychiatric disorders based on the national epidemiologic survey on alcohol and related conditions (NESARC)

AU - Blanco, Carlos

AU - Wall, Melanie M.

AU - Lindquist, Martin

AU - Rodruez-Ferndez, Jorge Mario

AU - Franco, Silvia

AU - Wang, Shuai

AU - Olfson, Mark

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Objective: Although neuroimaging studies have an important role in psychiatric nosology and treatment development, little is known about the representativeness of participants in neuroimaging research. We estimated the effects of commonly used study eligibility criteria on the representativeness of neuroimaging research participants in relation to the general population with the psychiatric disorders of interest. Methods: Common eligibility criteria were applied from 112 published neuroimaging studies of DSM-IV nicotine dependence (13 studies), alcohol dependence (12 studies), drug use disorders (13 studies), major depressive disorder (MDD) (37 studies), and posttraumatic stress disorder (PTSD) (36 studies) to representative US samples with these conditions from the 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) (n = 43,093). The analyses were repeated with NESARC respondents with the disorders and substantial psychosocial impairment. Results: Most NESARC respondents with nicotine dependence (64.1%), alcohol dependence (57.7%), drug use disorders (86.6%), and PTSD (66.9%), though not with MDD (18.2%), would have been excluded by eligibility criteria used in at least half of the relevant neuroimaging studies. Across the diagnostic groups, comorbid psychiatric and general medical conditions resulted in the largest percentages of exclusions. Corresponding analyses limited to respondents with substantial impairment excluded larger percentages with nicotine dependence (77.6%), alcohol dependence (75.8%), drug use disorders (93.5%), and PTSD (76.8%), though not MDD (18.3%). Conclusions: Neuroimaging studies tend to recruit highly selected samples with the psychiatric disorders of interest that markedly underrepresent individuals with common comorbid conditions. Larger studies with less restrictive eligibility criteria may promote translation of advances in neuroimaging research to populations commonly encountered in clinical practice.

AB - Objective: Although neuroimaging studies have an important role in psychiatric nosology and treatment development, little is known about the representativeness of participants in neuroimaging research. We estimated the effects of commonly used study eligibility criteria on the representativeness of neuroimaging research participants in relation to the general population with the psychiatric disorders of interest. Methods: Common eligibility criteria were applied from 112 published neuroimaging studies of DSM-IV nicotine dependence (13 studies), alcohol dependence (12 studies), drug use disorders (13 studies), major depressive disorder (MDD) (37 studies), and posttraumatic stress disorder (PTSD) (36 studies) to representative US samples with these conditions from the 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) (n = 43,093). The analyses were repeated with NESARC respondents with the disorders and substantial psychosocial impairment. Results: Most NESARC respondents with nicotine dependence (64.1%), alcohol dependence (57.7%), drug use disorders (86.6%), and PTSD (66.9%), though not with MDD (18.2%), would have been excluded by eligibility criteria used in at least half of the relevant neuroimaging studies. Across the diagnostic groups, comorbid psychiatric and general medical conditions resulted in the largest percentages of exclusions. Corresponding analyses limited to respondents with substantial impairment excluded larger percentages with nicotine dependence (77.6%), alcohol dependence (75.8%), drug use disorders (93.5%), and PTSD (76.8%), though not MDD (18.3%). Conclusions: Neuroimaging studies tend to recruit highly selected samples with the psychiatric disorders of interest that markedly underrepresent individuals with common comorbid conditions. Larger studies with less restrictive eligibility criteria may promote translation of advances in neuroimaging research to populations commonly encountered in clinical practice.

UR - http://www.scopus.com/inward/record.url?scp=85007601533&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85007601533&partnerID=8YFLogxK

U2 - 10.4088/JCP.15m10264

DO - 10.4088/JCP.15m10264

M3 - Article

C2 - 28086006

AN - SCOPUS:85007601533

VL - 77

SP - e1618-e1625

JO - Journal of Clinical Psychiatry

JF - Journal of Clinical Psychiatry

SN - 0160-6689

IS - 12

ER -