@article{4dd2344aeb024088b282879e28146b9b,
title = "General personality dimensions, impairment and treatment response in obsessive–compulsive disorder",
abstract = "General personality dimensions are associated with clinical severity and treatment response in individuals with depression and many anxiety disorders, but little is known about these relationships in individuals with obsessive–compulsive disorder (OCD). Individuals in the current study included 705 adults with OCD who had participated in family and genetic studies of the disorder. Participants self-completed the Neuroticism, Extraversion, Openness Personality Inventory or Neuroticism, Extraversion, Openness Five-Factor Inventory-3. Relationships between personality scores, and subjective impairment and OCD treatment response, were evaluated. The odds of subjective impairment increased with (unit increase in) the neuroticism score (odds ratio, OR = 1.03; 95% CI = 1.01–1.04; p < 0.01) and decreased with extraversion scores (OR = 0.98; 95% CI = 0.96–0.99; p < 0.01). The odds of reporting a good response to serotonin/selective serotonin reuptake inhibitors (OR = 1.02; 95% CI = 1.01–1.04; p < 0.01) or cognitive behavioural therapy (OR = 1.03; 95% CI = 1.01–1.05; p < 0.01) increased with the extraversion score. The magnitude of these relationships did not change appreciably after adjusting for other clinical features related to one or more of the personality dimensions. The findings suggest that neuroticism and extraversion are associated with subjective impairment, and that extraversion is associated with self-reported treatment response, in individuals with OCD.",
author = "Jack Samuels and Bienvenu, {O. Joseph} and Janice Krasnow and Ying Wang and Grados, {Marco A.} and Bernadette Cullen and Goes, {Fernando S.} and Brion Maher and Greenberg, {Benjamin D.} and Mclaughlin, {Nicole C.} and Rasmussen, {Steven A.} and Fyer, {Abby J.} and Knowles, {James A.} and Mccracken, {James T.} and John Piacentini and Dan Geller and Stewart, {S. Evelyn} and Murphy, {Dennis L.} and Shugart, {Yin Yao} and Riddle, {Mark A.} and Gerald Nestadt",
note = "Funding Information: This work was supported by the National Institutes of Health [MH50214, MH071507, MH79487, MH079488, MH079489, MH079494, K23‐MH‐64543, NIH/NCRR/OPD‐GCRC RR00052] and by the James E. Marshall OCD Foundation. The funding agencies had no role in the design or conduct of the study; collection, management, analysis or interpretation of the data; or preparation, review or approval of the manuscript. The views expressed in this report are those of the authors and do not necessarily represent the views of the National Institute of Mental Health, National Institutes of Health, United States Department of Health & Human Services, or the United States government. Funding Information: This work was supported by the National Institutes of Health [MH50214, MH071507, MH79487, MH079488, MH079489, MH079494, K23-MH-64543, NIH/NCRR/OPD-GCRC RR00052] and by the James E. Marshall OCD Foundation. The funding agencies had no role in the design or conduct of the study; collection, management, analysis or interpretation of the data; or preparation, review or approval of the manuscript. The views expressed in this report are those of the authors and do not necessarily represent the views of the National Institute of Mental Health, National Institutes of Health, United States Department of Health & Human Services, or the United States government. Publisher Copyright: {\textcopyright} 2019 John Wiley & Sons, Ltd.",
year = "2020",
month = may,
day = "1",
doi = "10.1002/pmh.1472",
language = "English (US)",
volume = "14",
pages = "186--198",
journal = "Personality and Mental Health",
issn = "1932-8621",
publisher = "John Wiley and Sons Ltd",
number = "2",
}