Improving child cognition in impoverished countries is a public health priority. Yet, biological pathways and associated biomarkers of impaired cognition remain poorly understood and largely unknown, respectively. This study aimed to explore and quantify associations between functional plasma protein biomarkers and childhood intellectual test performance. We applied proteomics to quantify proteins in plasma samples of 249 rural Nepalese children, 6-8. years of age who, 1. year later at 7-9. years of age, were administered the Universal Nonverbal Intelligence Test (UNIT). Among 751 plasma proteins quantified, 22 were associated with UNIT scores, passing a false discovery rate threshold of 5.0% (q.
- Cohort study
- Mass spectrometry
- Plasma proteomics
- Universal Nonverbal Intelligence Test
ASJC Scopus subject areas
- Behavioral Neuroscience
- Endocrine and Autonomic Systems